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Tchem
NAA50
N-alpha-acetyltransferase 50

Protein Summary
Description
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240922
  • ENSP00000240922
  • ENSG00000121579

Symbol
  • MAK3
  • NAT13
  • NAT5
  • SAN
  • MAK3
  • NAT5
  • NAT13
  • NAT5P
  • NAT13P
  • hNaa50p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
microRNA
0.87
histone modification site profile
0.84
transcription factor binding site profile
0.83
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.33   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.33   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (164)
NAA15
Tbio
Family:  Enzyme
Novelty:  0.00513055
p_int:  0.999999883
p_ni:  1.17e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
TSGA10IP
Tdark
Novelty:  20.75428866
p_int:  0.991878705
p_ni:  0.008109942
p_wrong:  0.000011354
Score:  0.188
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.940332887
p_ni:  0.059667113
p_wrong:  1e-9
Data Source:  BioPlex
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.934615152
p_ni:  0.065384848
Score:  0.223
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.917565899
p_ni:  0.0824341
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.900801607
p_ni:  0.098838676
p_wrong:  0.000359717
Score:  0.333
Data Source:  BioPlex,STRINGDB
RNF26
Tbio
Novelty:  0.40088751
p_int:  0.821674195
p_ni:  0.178323429
p_wrong:  0.000002377
Score:  0.199
Data Source:  BioPlex,STRINGDB
MOK
Tbio
Family:  Kinase
Novelty:  0.0116106
p_int:  0.763685784
p_ni:  0.2363084
p_wrong:  0.000005816
Score:  0.28
Data Source:  BioPlex,STRINGDB
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.763685784
p_ni:  0.2363084
p_wrong:  0.000005816
Data Source:  BioPlex
MBD5
Tbio
Family:  Epigenetic
Novelty:  0.03015349
p_int:  0.755082852
p_ni:  0.244917147
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
femoral neck bone mineral density
1
1
1
60.3
parental genotype effect measurement
1
1
1
35
birth weight
1
1
1
35
ceramide measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
femoral neck bone mineral density
1
60.3
parental genotype effect measurement
1
35
birth weight
1
35
ceramide measurement
1
12.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
N(alpha)-acetyltransferase 50, NatE catalytic subunit
709764
Mouse
MGI:1919367
72117
Rat
RGD:1310944
288108
Rat
Horse
N(alpha)-acetyltransferase 50, NatE catalytic subunit
100071372
Species
Name
OMA
EggNOG
Inparanoid
Macaque
N(alpha)-acetyltransferase 50, NatE catalytic subunit
Mouse
Rat
Rat
Horse
N(alpha)-acetyltransferase 50, NatE catalytic subunit
Publication Statistics
PubMed Score 137.33
PubMed score by year
PubTator Score 302.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title