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Tbio
NAA40
N-alpha-acetyltransferase 40

Protein Summary
Description
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377793
  • ENSP00000367024
  • ENSG00000110583
  • ENST00000542163
  • ENSP00000442055

Symbol
  • NAT11
  • PATT1
  • NatD
  • NAT11
  • PATT1
  • hNatD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.7
transcription factor perturbation
0.68
tissue
0.57
transcription factor
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.99994883
p_ni:  0.000049954
p_wrong:  0.000001217
Score:  0.173
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.996495725
p_ni:  0.003504275
Data Source:  BioPlex
ANGEL2
Tbio
Novelty:  0.26130802
p_int:  0.995602188
p_ni:  0.004397812
Score:  0.211
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.995581913
p_ni:  0.004418087
Score:  0.542
Data Source:  BioPlex,STRINGDB
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
p_int:  0.995221894
p_ni:  0.004778106
Score:  0.648
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.993492212
p_ni:  0.006507787
Score:  0.798
Data Source:  BioPlex,STRINGDB
TPP2
Tchem
Family:  Enzyme
Novelty:  0.00803674
p_int:  0.987194159
p_ni:  0.01280584
Score:  0.212
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.972831331
p_ni:  0.027168669
Score:  0.636
Data Source:  BioPlex,STRINGDB
H2AFY
Tbio
Novelty:  0.01150729
p_int:  0.966940558
p_ni:  0.033059442
Score:  0.38
Data Source:  BioPlex,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.935080771
p_ni:  0.064919228
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
Name
Explore in Pharos
Explore in Source
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1
59.2
pulse pressure measurement
1
1
2
56.7
1
1
0
1
43
systolic blood pressure
1
1
1
33.4
schizophrenia
1
1
1
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
59.2
pulse pressure measurement
2
56.7
0
1
43
systolic blood pressure
1
33.4
schizophrenia
1
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 40, NatD catalytic subunit
VGNC:8188
466645
Macaque
N(alpha)-acetyltransferase 40, NatD catalytic subunit
722126
Mouse
MGI:1918249
70999
Rat
RGD:1565838
361718
Dog
N(alpha)-acetyltransferase 40, NatD catalytic subunit
VGNC:51882
476041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 40, NatD catalytic subunit
Macaque
N(alpha)-acetyltransferase 40, NatD catalytic subunit
Mouse
Rat
Dog
N(alpha)-acetyltransferase 40, NatD catalytic subunit
Publication Statistics
PubMed Score 21.82
PubMed score by year
PubTator Score 3.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title