Tbio NAA40 N-alpha-acetyltransferase 40

Protein Summary

Description

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity).

Uniprot Accession IDs

• Q86UY6
• B4DR03
• B4DU10
• Q5HYL5
• Q9H897

Gene Name

• NAA40

Ensembl ID

• ENST00000377793
• ENSP00000367024
• ENSG00000110583
• ENST00000542163
• ENSP00000442055

Symbol

• NAT11
• PATT1
• NatD
• NAT11
• PATT1
• hNatD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
transcription factor binding site profile	0.7
transcription factor perturbation	0.68
tissue	0.57
transcription factor	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0