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Tbio
NAA30
N-alpha-acetyltransferase 30

Protein Summary
Description
Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000556492
  • ENSP00000452521
  • ENSG00000139977

Symbol
  • C14orf35
  • MAK3
  • NAT12
  • MAK3
  • Mak3p
  • NAT12
  • NAT12P
  • C14orf35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.88
co-expressed gene
0.85
microRNA
0.72
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
NAA35
Tbio
Family:  Enzyme
Novelty:  0.04980045
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
NAA38
Tdark
Family:  Enzyme
Novelty:  19.36506889
p_int:  0.999999833
p_ni:  1.67e-7
p_wrong:  1e-9
Score:  0.974
Data Source:  BioPlex,Reactome,STRINGDB
MAP4K2
Tchem
Family:  Kinase
Novelty:  0.02195042
p_int:  0.999956365
p_ni:  5.5e-8
p_wrong:  0.00004358
Data Source:  BioPlex
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.999926607
p_ni:  0.000060896
p_wrong:  0.000012497
Data Source:  BioPlex
CCDC28B
Tbio
Novelty:  0.16787198
p_int:  0.99987167
p_ni:  0.00007549
p_wrong:  0.00005284
Data Source:  BioPlex
RTKN
Tbio
Novelty:  0.01044337
p_int:  0.998388517
p_ni:  0.001604931
p_wrong:  0.000006552
Data Source:  BioPlex
BTF3
Tbio
Novelty:  0.01198537
p_int:  0.997919864
p_ni:  0.00018199
p_wrong:  0.001898146
Data Source:  BioPlex
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.997323713
p_ni:  0.000007296
p_wrong:  0.002668991
Score:  0.318
Data Source:  BioPlex,STRINGDB
ISYNA1
Tbio
Family:  Enzyme
Novelty:  0.00302974
p_int:  0.961948224
p_ni:  0.038051776
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.936383117
p_ni:  0.063616883
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
1
3
33.8
basophil percentage of leukocytes
1
1
1
32
gait measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
33.8
basophil percentage of leukocytes
1
32
gait measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 30, NatC catalytic subunit
VGNC:8203
452931
Macaque
N(alpha)-acetyltransferase 30, NatC catalytic subunit
699379
Mouse
MGI:1922259
70646
Rat
RGD:1559923
498489
Dog
N(alpha)-acetyltransferase 30, NatC catalytic subunit
VGNC:50549
612880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 30, NatC catalytic subunit
Macaque
N(alpha)-acetyltransferase 30, NatC catalytic subunit
Mouse
Rat
Dog
N(alpha)-acetyltransferase 30, NatC catalytic subunit
Publication Statistics
PubMed Score 32.71
PubMed score by year
PubTator Score 6.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title