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Tbio
NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Protein Summary
Description
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261745
  • ENSP00000261745
  • ENSG00000111300

Symbol
  • C12orf30
  • MDM20
  • NAP1
  • NAP1
  • MDM20
  • C12orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.76
transcription factor binding site profile
0.73
microRNA
0.68
histone modification site profile
0.66
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
REG1A
Tbio
Novelty:  0.00492251
p_int:  0.999999986
p_ni:  1.3e-8
Data Source:  BioPlex
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.999999968
p_ni:  2.3e-8
p_wrong:  1e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
TNFRSF8
Tclin
Novelty:  0.00030231
p_int:  0.999999168
p_ni:  8.32e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
p_int:  0.998573728
p_ni:  0.000321515
p_wrong:  0.001104757
Score:  0.379
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.920691519
p_ni:  0.000895785
p_wrong:  0.078412696
Score:  0.205
Data Source:  BioPlex,STRINGDB
NAA20
Tbio
Family:  Enzyme
Novelty:  0.07814789
Score:  0.999
Data Source:  STRINGDB
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
Score:  0.961
Data Source:  STRINGDB
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
Score:  0.959
Data Source:  STRINGDB
NAA15
Tbio
Family:  Enzyme
Novelty:  0.00513055
Score:  0.955
Data Source:  STRINGDB
NAA35
Tbio
Family:  Enzyme
Novelty:  0.04980045
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
2
98
energy intake
1
2
0
1.7
97.1
high density lipoprotein cholesterol measurement
2
2
2
96.1
blood urea nitrogen measurement
2
2
2
95.1
serum gamma-glutamyl transferase measurement
1
1
1
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
98
energy intake
0
1.7
97.1
high density lipoprotein cholesterol measurement
2
96.1
blood urea nitrogen measurement
2
95.1
serum gamma-glutamyl transferase measurement
1
94.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
VGNC:8468
452258
Macaque
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
713583
Mouse
MGI:2442563
231713
Rat
RGD:1305685
360811
Dog
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
VGNC:52953
486274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Macaque
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Mouse
Rat
Dog
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Publication Statistics
PubMed Score 20.43
PubMed score by year
PubTator Score 5.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title