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Tbio
MYT1L
Myelin transcription factor 1-like protein

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399161
  • ENSP00000382114
  • ENSG00000186487
  • ENST00000407844
  • ENSP00000384219
  • ENST00000428368
  • ENSP00000396103
  • ENST00000647694
  • ENSP00000497722
  • ENST00000647738
  • ENSP00000497479
  • ENST00000648316
  • ENSP00000497870
  • ENST00000648928
  • ENSP00000497017
  • ENST00000649207
  • ENSP00000496986

Symbol
  • KIAA1106
  • NZF1
  • MRD39
  • myT1-L
  • ZC2H2C2
  • ZC2HC4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
trait
0.86
transcription factor perturbation
0.68
disease
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.863
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.856
Data Source:  STRINGDB
POU3F3
Tbio
Family:  TF
Novelty:  0.00954977
Score:  0.776
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.767
Data Source:  STRINGDB
NEUROD2
Tbio
Family:  TF
Novelty:  0.01822347
Score:  0.758
Data Source:  STRINGDB
PXDN
Tbio
Novelty:  0.00935722
Score:  0.693
Data Source:  STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
Score:  0.666
Data Source:  STRINGDB
NEUROG2
Tbio
Family:  TF
Novelty:  0.00489481
Score:  0.66
Data Source:  STRINGDB
NKX2-2
Tbio
Family:  TF
Novelty:  0.00608835
Score:  0.596
Data Source:  STRINGDB
ZNF804A
Tbio
Novelty:  0.00751648
Score:  0.595
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
33.1
alcohol consumption measurement
1
1
1
26.6
gut microbiome measurement
1
1
0
5.5
17.8
risk-taking behaviour
1
1
1
17.8
erosive tooth wear measurement
1
1
0
3.5
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
33.1
alcohol consumption measurement
1
26.6
gut microbiome measurement
0
5.5
17.8
risk-taking behaviour
1
17.8
erosive tooth wear measurement
0
3.5
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myelin transcription factor 1 like
VGNC:314
458998
Macaque
myelin transcription factor 1 like
706914
Mouse
MGI:1100511
17933
Rat
RGD:620550
116668
Dog
myelin transcription factor 1 like
VGNC:43592
482954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myelin transcription factor 1 like
Macaque
myelin transcription factor 1 like
Mouse
Rat
Dog
myelin transcription factor 1 like
Publication Statistics
PubMed Score 60.20
PubMed score by year
PubTator Score 28.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title