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Tbio
MYSM1
Histone H2A deubiquitinase MYSM1

Protein Summary
Description
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000472487
  • ENSP00000418734
  • ENSG00000162601
  • ENST00000622766
  • ENSP00000478391

Symbol
  • KIAA1915
  • 2ADUB
  • BMFS4
  • 2A-DUB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cell type or tissue
0.71
microRNA
0.68
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.55   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.55   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.999999996
p_wrong:  4e-9
Data Source:  BioPlex
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.987
Data Source:  Reactome,STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.977
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.976
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.965
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.962
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.962
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.947
Data Source:  Reactome,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
Score:  0.918
Data Source:  STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Metalloprotease DUBs
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Metalloprotease DUBs
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Myb like, SWIRM and MPN domains 1
VGNC:8077
456892
Macaque
Myb like, SWIRM and MPN domains 1
718013
Mouse
MGI:2444584
320713
Rat
RGD:1311787
298247
Dog
Myb like, SWIRM and MPN domains 1
VGNC:43590
489568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Myb like, SWIRM and MPN domains 1
Macaque
Myb like, SWIRM and MPN domains 1
Mouse
Rat
Dog
Myb like, SWIRM and MPN domains 1
Publication Statistics
PubMed Score 38.55
PubMed score by year
PubTator Score 12.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title