Tbio MYOG Myogenin

Protein Summary

Description

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15173
• Q53XW6

Gene Name

• MYOG

Ensembl ID

• ENST00000241651
• ENSP00000241651
• ENSG00000122180

Symbol

• BHLHC3
• MYF4
• MYF4
• myf-4
• bHLHc3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
molecular function	0.95
gene perturbation	0.65
tissue	0.65
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenin

Protein / Nucleic Acid Binding / Myogenin

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.2   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 1009   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.2   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 1009   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (220)

Explore Interacting Targets

1 – 10 of 220

• See Interactions on String-DB

TCF12

Tbio

Family:  TF

Novelty:  0.00381424

p_int:  0.999990796

p_ni:  0.000009204

Score:  0.991

Data Source:  BioPlex,STRINGDB

TCF4

Tbio

Family:  TF

Novelty:  0.0019718

p_int:  0.999944702

p_ni:  0.00005529

p_wrong:  8e-9

Score:  0.989

Data Source:  BioPlex,STRINGDB

TCF3

Tbio

Family:  TF

Novelty:  0.00112675

p_int:  0.978505325

p_ni:  0.021494674

p_wrong:  1e-9

Score:  0.992

Data Source:  BioPlex,Reactome,STRINGDB

NES

Tbio

Novelty:  0.00035379

p_int:  0.843885118

p_ni:  0.020879581

p_wrong:  0.135235301

Score:  0.778

Data Source:  BioPlex,STRINGDB

ID4

Tbio

Family:  TF

Novelty:  0.00399089

p_int:  0.782555675

p_ni:  0.000538307

p_wrong:  0.216906018

Score:  0.838

Data Source:  BioPlex,STRINGDB

MEF2C

Tbio

Family:  TF

Novelty:  0.00232724

Score:  0.988

Data Source:  Reactome,STRINGDB

MEF2A

Tbio

Family:  TF

Novelty:  0.00439393

Score:  0.988

Data Source:  Reactome,STRINGDB

MEF2D

Tbio

Family:  TF

Novelty:  0.00732653

Score:  0.98

Data Source:  STRINGDB

MYOD1

Tbio

Family:  TF

Novelty:  0.00053412

Score:  0.947

Data Source:  STRINGDB

PAX7

Tbio

Family:  TF

Novelty:  0.00142843

Score:  0.945

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (2)

PathwayCommons (2)

WikiPathways (3)

Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Myogenesis	29 targets	R-HSA-525793

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Myogenesis	29 targets	R-HSA-525793

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (49)

Functions (11)

Components (4)

Processes (34)

Find Similar Targets

Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
E-box binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein heterodimerization activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Disease Associations (null)

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	4	4	0	1.1	92.2
childhood onset asthma	EFO_0004591	2	1	0	1.1	73.5
asthma	EFO_0000270	5	5	0	1	70.9
systolic blood pressure	EFO_0006335	1	1	1		42.3
waist-hip ratio	EFO_0004343	1	1	1		28.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	0	1.1	92.2
childhood onset asthma	EFO_0004591	0	1.1	73.5
asthma	EFO_0000270	0	1	70.9
systolic blood pressure	EFO_0006335	1		42.3
waist-hip ratio	EFO_0004343	1		28.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Cell cycle
Complete proteome
Developmental protein
Differentiation
DNA-binding
Myogenesis
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
asthma
atrial fibrillation
BMI-adjusted waist-hip ratio
childhood onset asthma
ganglion cell inner plexiform layer thickness measurement
systolic blood pressure
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
muscle phenotype
respiratory system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myogenin	VGNC:11554	469647
Mouse	myogenin	MGI:97276	17928
Rat	myogenin	RGD:620432	29148
Dog	myogenin	VGNC:43580	490224
Horse	myogenin	VGNC:20518	100146744

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myogenin
Mouse	myogenin
Rat	myogenin
Dog	myogenin
Horse	myogenin

Publication Statistics

PubMed Score 1236.20

PubMed score by year

Reset Zoom

PubTator Score 524.88

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (55)

GeneRif Annotations (25)

Items per page:

10

0 of 0

PMID	Year	Title