Protein Summary
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late ...more
- ENST00000241651
- ENSP00000241651
- ENSG00000122180
- BHLHC3
- MYF4
- MYF4
- myf-4
- bHLHc3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.98 | ||
molecular function | 0.95 | ||
gene perturbation | 0.65 | ||
tissue | 0.65 | ||
cellular component | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1236.2 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 1009 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1236.2 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 1009 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (220)
TCF12
Family: TF
Novelty: 0.00381424
p_int: 0.999990796
p_ni: 0.000009204
Score: 0.991
Data Source: BioPlex,STRINGDB
TCF4
Family: TF
Novelty: 0.0019718
p_int: 0.999944702
p_ni: 0.00005529
p_wrong: 8e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
TCF3
Family: TF
Novelty: 0.00112675
p_int: 0.978505325
p_ni: 0.021494674
p_wrong: 1e-9
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
NES
Novelty: 0.00035379
p_int: 0.843885118
p_ni: 0.020879581
p_wrong: 0.135235301
Score: 0.778
Data Source: BioPlex,STRINGDB
ID4
Family: TF
Novelty: 0.00399089
p_int: 0.782555675
p_ni: 0.000538307
p_wrong: 0.216906018
Score: 0.838
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (2)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Myogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Myogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (11)
Components (4)
Processes (34)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 1.1 | 92.2 | |||||
childhood onset asthma | 2 | 1 | 0 | 1.1 | 73.5 | ||||
5 | 5 | 0 | 1 | 70.9 | |||||
systolic blood pressure | 1 | 1 | 1 | 42.3 | |||||
waist-hip ratio | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 92.2 | |||||
childhood onset asthma | 0 | 1.1 | 73.5 | ||||
0 | 1 | 70.9 | |||||
systolic blood pressure | 1 | 42.3 | |||||
waist-hip ratio | 1 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | myogenin | VGNC:11554 | 469647 | |||||
Mouse | MGI:97276 | 17928 | ||||||
Rat | RGD:620432 | 29148 | ||||||
Dog | myogenin | VGNC:43580 | 490224 | |||||
Horse | myogenin | VGNC:20518 | 100146744 | |||||
Publication Statistics
PubMed Score 1236.20
PubMed score by year
PubTator Score 524.88
PubTator score by year
Related Publications
Text Mined References (55)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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