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Tbio
MYOG
Myogenin

Protein Summary
Description
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241651
  • ENSP00000241651
  • ENSG00000122180

Symbol
  • BHLHC3
  • MYF4
  • MYF4
  • myf-4
  • bHLHc3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.95
gene perturbation
0.65
tissue
0.65
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.2   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 1009   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.2   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 1009   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (220)
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999990796
p_ni:  0.000009204
Score:  0.991
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999944702
p_ni:  0.00005529
p_wrong:  8e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.978505325
p_ni:  0.021494674
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
NES
Tbio
Novelty:  0.00035379
p_int:  0.843885118
p_ni:  0.020879581
p_wrong:  0.135235301
Score:  0.778
Data Source:  BioPlex,STRINGDB
ID4
Tbio
Family:  TF
Novelty:  0.00399089
p_int:  0.782555675
p_ni:  0.000538307
p_wrong:  0.216906018
Score:  0.838
Data Source:  BioPlex,STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.988
Data Source:  Reactome,STRINGDB
MEF2A
Tbio
Family:  TF
Novelty:  0.00439393
Score:  0.988
Data Source:  Reactome,STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.98
Data Source:  STRINGDB
MYOD1
Tbio
Family:  TF
Novelty:  0.00053412
Score:  0.947
Data Source:  STRINGDB
PAX7
Tbio
Family:  TF
Novelty:  0.00142843
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
92.2
childhood onset asthma
2
1
0
1.1
73.5
5
5
0
1
70.9
systolic blood pressure
1
1
1
42.3
waist-hip ratio
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.2
childhood onset asthma
0
1.1
73.5
0
1
70.9
systolic blood pressure
1
42.3
waist-hip ratio
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myogenin
VGNC:11554
469647
Mouse
MGI:97276
17928
Rat
RGD:620432
29148
Dog
myogenin
VGNC:43580
490224
Horse
myogenin
VGNC:20518
100146744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myogenin
Mouse
Rat
Dog
myogenin
Horse
myogenin
Publication Statistics
PubMed Score 1236.20
PubMed score by year
PubTator Score 524.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title