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Tbio
MYOCD
Myocardin

Protein Summary
Description
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343344
  • ENSP00000341835
  • ENSG00000141052
  • ENST00000425538
  • ENSP00000401678

Symbol
  • MYCD
  • MYCD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.94
transcription factor
0.72
gene perturbation
0.65
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.4   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.4   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.994
Data Source:  STRINGDB
ELK1
Tbio
Family:  TF
Novelty:  0.21670414
Score:  0.956
Data Source:  STRINGDB
TAGLN
Tbio
Novelty:  0.00243855
Score:  0.951
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.905
Data Source:  STRINGDB
MDK
Tchem
Novelty:  0.00145301
Score:  0.877
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.841
Data Source:  STRINGDB
ACTC1
Tbio
Novelty:  0.00188036
Score:  0.807
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.805
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.799
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.789
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
50.6
electrocardiography
1
1
5
36.9
PR interval
1
1
0
1.4
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
50.6
electrocardiography
5
36.9
PR interval
0
1.4
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocardin
VGNC:9451
455063
Macaque
myocardin
718193
Mouse
MGI:2137495
214384
Rat
RGD:631347
246297
Dog
myocardin
VGNC:43577
489509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocardin
Macaque
myocardin
Mouse
Rat
Dog
myocardin
Publication Statistics
PubMed Score 318.40
PubMed score by year
PubTator Score 84.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title