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Tbio
MYO5B
Unconventional myosin-Vb

Protein Summary
Description
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285039
  • ENSP00000285039
  • ENSG00000167306
  • ENST00000592688
  • ENSP00000466368

Symbol
  • KIAA1119
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
transcription factor perturbation
0.98
gene perturbation
0.9
PubMedID
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.31   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.31   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.99999995
p_ni:  4.7e-8
p_wrong:  2e-9
Score:  0.265
Data Source:  BioPlex,STRINGDB
TMOD1
Tbio
Novelty:  0.01142927
p_int:  0.999999491
p_ni:  5.08e-7
p_wrong:  1e-9
Score:  0.271
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.999999094
p_ni:  9.06e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999998107
p_ni:  0.000001893
Score:  0.17
Data Source:  BioPlex,STRINGDB
TNNC1
Tclin
Novelty:  0.03535727
p_int:  0.999995094
p_ni:  0.000004906
p_wrong:  1e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
MYL2
Tbio
Novelty:  0.0018887
p_int:  0.999658514
p_ni:  0.000340533
p_wrong:  9.53e-7
Score:  0.376
Data Source:  BioPlex,STRINGDB
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.999632871
p_ni:  0.000367125
p_wrong:  4e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.998322992
p_ni:  0.000718779
p_wrong:  0.000958229
Data Source:  BioPlex
LRRC39
Tdark
Novelty:  0.70657884
p_int:  0.986449849
p_ni:  0.009023883
p_wrong:  0.004526269
Score:  0.291
Data Source:  BioPlex,STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
14
15
99.2
high density lipoprotein cholesterol measurement
9
14
26
98.7
total cholesterol measurement
1
5
5
91.2
Myopia
2
1
0
4.1
66.8
refractive error measurement
2
1
1
7.1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
15
99.2
high density lipoprotein cholesterol measurement
26
98.7
total cholesterol measurement
5
91.2
Myopia
0
4.1
66.8
refractive error measurement
1
7.1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VB
VGNC:13270
455415
Macaque
myosin VB
699592
Mouse
MGI:106598
17919
Rat
RGD:621347
25132
Dog
myosin VB
VGNC:43569
480220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VB
Macaque
myosin VB
Mouse
Rat
Dog
myosin VB
Publication Statistics
PubMed Score 89.31
PubMed score by year
PubTator Score 48.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title