Tbio MYO5A Unconventional myosin-Va

Protein Summary

Description

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q9Y4I1
• A8MZC5
• O60653
• Q07902
• Q16249
• Q9UE30
• Q9UE31

Gene Name

• MYO5A

Ensembl ID

• ENST00000356338
• ENSP00000348693
• ENSG00000197535
• ENST00000399231
• ENSP00000382177

Symbol

• MYH12
• GS1
• MYO5
• MYH12
• MYR12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
virus perturbation	0.98
biological process	0.97
hub protein	0.97
transcription factor perturbation	0.97

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Unconventional Myosin-va

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-va

Protein / Cell Junction Protein / Unconventional Myosin-va

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-va

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.24   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.24   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0