Protein Summary
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase do ...more
- ENST00000265944
- ENSP00000265944
- ENSG00000095777
- ENST00000376302
- ENSP00000365479
- ENST00000642920
- ENSP00000495965
- DFNB30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
protein domain | 0.92 | ||
pathway | 0.63 | ||
cell type or tissue | 0.59 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.84 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 136 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.84 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 136 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (100)
MYL12B
Novelty: 0.00999083
p_int: 0.999999914
p_ni: 3.1e-8
p_wrong: 5.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
TNNC1
Novelty: 0.03535727
p_int: 0.999999865
p_ni: 8.8e-8
p_wrong: 4.7e-8
Score: 0.273
Data Source: BioPlex,STRINGDB
MORN4
Novelty: 0.22826325
p_int: 0.887864336
p_ni: 0.000152273
p_wrong: 0.111983391
Score: 0.862
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cytoskeletal regulation by Rho GTPase | ||||
PathwayCommons: panther | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
PathwayCommons: panther | Nicotinic acetylcholine receptor signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytoskeletal regulation by Rho GTPase | ||||
Inflammation mediated by chemokine and cytokine signaling pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (9)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 1 | 1 | 59.6 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glucose measurement | 1 | 59.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myosin IIIA | VGNC:12381 | 450359 | |||||
Macaque | myosin IIIA | 707165 | ||||||
Mouse | MGI:2183924 | 667663 | ||||||
Rat | RGD:1560083 | 498806 | ||||||
Dog | myosin IIIA | VGNC:43567 | 487106 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myosin IIIA | |||||
Macaque | myosin IIIA | |||||
Mouse | ||||||
Rat | ||||||
Dog | myosin IIIA | |||||
Publication Statistics
PubMed Score 32.84
PubMed score by year
PubTator Score 22.86
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (27)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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