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Tbio
MYO3A
Myosin-IIIa

Protein Summary
Description
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265944
  • ENSP00000265944
  • ENSG00000095777
  • ENST00000376302
  • ENSP00000365479
  • ENST00000642920
  • ENSP00000495965

Symbol
  • DFNB30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
pathway
0.63
cell type or tissue
0.59
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.84   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.84   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.999999914
p_ni:  3.1e-8
p_wrong:  5.5e-8
Score:  0.285
Data Source:  BioPlex,STRINGDB
TNNC1
Tclin
Novelty:  0.03535727
p_int:  0.999999865
p_ni:  8.8e-8
p_wrong:  4.7e-8
Score:  0.273
Data Source:  BioPlex,STRINGDB
MORN4
Tdark
Novelty:  0.22826325
p_int:  0.887864336
p_ni:  0.000152273
p_wrong:  0.111983391
Score:  0.862
Data Source:  BioPlex,STRINGDB
ESPN
Tbio
Novelty:  0.0035928
Score:  0.963
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.922
Data Source:  STRINGDB
MYO1A
Tbio
Novelty:  0.00942771
Score:  0.918
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.917
Data Source:  STRINGDB
MYO1C
Tbio
Novelty:  0.00967011
Score:  0.917
Data Source:  STRINGDB
PDLIM4
Tbio
Novelty:  0.01308013
Score:  0.915
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cytoskeletal regulation by Rho GTPase
PathwayCommons: panther
Inflammation mediated by chemokine and cytokine signaling pathway
PathwayCommons: panther
Nicotinic acetylcholine receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
1
59.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IIIA
VGNC:12381
450359
Macaque
myosin IIIA
707165
Mouse
MGI:2183924
667663
Rat
RGD:1560083
498806
Dog
myosin IIIA
VGNC:43567
487106
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IIIA
Macaque
myosin IIIA
Mouse
Rat
Dog
myosin IIIA
Publication Statistics
PubMed Score 32.84
PubMed score by year
PubTator Score 22.86
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title