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Tbio
MYO1F
Unconventional myosin-If

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338257
  • ENSP00000344871
  • ENSG00000142347
  • ENST00000613525
  • ENSP00000481682
  • ENST00000644032
  • ENSP00000494550
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
ligand (protein) perturbation
0.83
gene perturbation
0.82
PubMedID
0.8
interacting protein
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
OSTF1
Tbio
Novelty:  0.000588
p_int:  0.999950646
p_ni:  0.000049353
p_wrong:  1e-9
Score:  0.339
Data Source:  BioPlex,STRINGDB
PYCR2
Tbio
Family:  Enzyme
Novelty:  0.05660996
p_int:  0.979778766
p_ni:  0.017853942
p_wrong:  0.002367292
Score:  0.513
Data Source:  BioPlex,STRINGDB
IL1RL2
Tbio
Novelty:  0.0156461
p_int:  0.948723889
p_ni:  0.050340954
p_wrong:  0.000935157
Score:  0.199
Data Source:  BioPlex,STRINGDB
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.941424741
p_ni:  0.058203373
p_wrong:  0.000371887
Score:  0.177
Data Source:  BioPlex,STRINGDB
INHBE
Tbio
Novelty:  0.07526145
p_int:  0.923417962
p_ni:  0.07570418
p_wrong:  0.000877858
Score:  0.206
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.895940323
p_ni:  0.027963749
p_wrong:  0.076095928
Data Source:  BioPlex
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.893060024
p_ni:  0.105782408
p_wrong:  0.001157568
Score:  0.201
Data Source:  BioPlex,STRINGDB
MYO18B
Tbio
Novelty:  0.0366177
Score:  0.916
Data Source:  STRINGDB
MYO1C
Tbio
Novelty:  0.00967011
Score:  0.913
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
8
13
97.6
BMI-adjusted hip circumference
2
6
8
96.7
body weights and measures
1
1
1
87.6
body fat distribution
3
1
5
83.5
basophil count
2
2
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
13
97.6
BMI-adjusted hip circumference
8
96.7
body weights and measures
1
87.6
body fat distribution
5
83.5
basophil count
2
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107711
17916
Rat
RGD:1309750
314654
Dog
myosin IF
VGNC:43565
485011
Cow
myosin IF
VGNC:31821
532964
Pig
myosin IF
100517998
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
myosin IF
Cow
myosin IF
Pig
myosin IF
Publication Statistics
PubMed Score 17.67
PubMed score by year
PubTator Score 7.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title