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Tbio
MYO1E
Unconventional myosin-Ie

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288235
  • ENSP00000288235
  • ENSG00000157483

Symbol
  • MYO1C
  • FSGS6
  • MYO1C
  • HuncM-IC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.88
interacting protein
0.84
transcription factor binding site profile
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.49   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.49   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.998941255
p_ni:  0.001058745
Score:  0.209
Data Source:  BioPlex,STRINGDB
OSTF1
Tbio
Novelty:  0.000588
p_int:  0.996622692
p_ni:  0.003377308
Score:  0.402
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.947788943
p_ni:  0.052211057
Score:  0.342
Data Source:  BioPlex,STRINGDB
UNC45A
Tbio
Novelty:  0.07503761
p_int:  0.917668322
p_ni:  0.082331678
Score:  0.587
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.766
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.758
Data Source:  STRINGDB
PITPNA
Tbio
Novelty:  0.01901136
Score:  0.749
Data Source:  STRINGDB
SCARF1
Tbio
Novelty:  0.00938046
Score:  0.749
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.736
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.735
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
2
56
phosphatidylethanolamine measurement
1
2
2
47.5
pulse pressure measurement
1
1
1
46.9
platelet crit
1
1
1
33.1
body height
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
56
phosphatidylethanolamine measurement
2
47.5
pulse pressure measurement
1
46.9
platelet crit
1
33.1
body height
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IE
VGNC:14643
453479
Macaque
myosin IE
100429961
Mouse
MGI:106621
71602
Rat
RGD:3144
25484
Dog
myosin IE
VGNC:43564
478325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IE
Macaque
myosin IE
Mouse
Rat
Dog
myosin IE
Publication Statistics
PubMed Score 76.49
PubMed score by year
PubTator Score 18.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title