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Tbio
MYO19
Unconventional myosin-XIX

Protein Summary
Description
Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610930
  • ENSP00000478437
  • ENSG00000278259
  • ENST00000610992
  • ENSP00000480125
  • ENST00000613929
  • ENSP00000478355
  • ENSG00000278372
  • ENST00000614623
  • ENSP00000479518
  • ENST00000618519
  • ENSP00000480242
  • ENST00000621344
  • ENSP00000477559
  • ENST00000633264
  • ENSP00000487617
  • ENST00000633938
  • ENSP00000488204

Symbol
  • MYOHD1
  • MYOHD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.94
cell type or tissue
0.82
transcription factor perturbation
0.8
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.999811518
p_ni:  0.000188482
Score:  0.251
Data Source:  BioPlex,STRINGDB
MYL2
Tbio
Novelty:  0.0018887
p_int:  0.994431867
p_ni:  0.005568133
Score:  0.357
Data Source:  BioPlex,STRINGDB
CETN3
Tbio
Novelty:  0.00705513
p_int:  0.992968469
p_ni:  0.007031522
p_wrong:  9e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
HLA-DQA1
Tbio
Novelty:  0.00077488
p_int:  0.982035001
p_ni:  0.017964999
Score:  0.188
Data Source:  BioPlex,STRINGDB
MYL10
Tdark
Novelty:  0.01378575
p_int:  0.978812579
p_ni:  0.021187421
Score:  0.627
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.94172799
p_ni:  0.05827201
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.921058811
p_ni:  0.078941189
Data Source:  BioPlex
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
p_int:  0.901594276
p_ni:  0.098405724
Score:  0.645
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.851418428
p_ni:  0.148581572
Score:  0.151
Data Source:  BioPlex,STRINGDB
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.777616127
p_ni:  0.222383872
Score:  0.631
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
5
5
98.6
macrophage inflammatory protein 1b measurement
1
5
5
98.6
CCL4 measurement
1
3
3
95.9
CCL4 measurement
1
3
3
95.9
red blood cell distribution width
4
4
4
93.9
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
5
98.6
macrophage inflammatory protein 1b measurement
5
98.6
CCL4 measurement
3
95.9
CCL4 measurement
3
95.9
red blood cell distribution width
4
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913446
66196
Rat
RGD:1559961
497974
Dog
myosin XIX
VGNC:43559
100855669
Horse
myosin XIX
VGNC:20498
100071404
Cow
myosin XIX
VGNC:31815
508229
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
myosin XIX
Horse
myosin XIX
Cow
myosin XIX
Publication Statistics
PubMed Score 14.03
PubMed score by year
PubTator Score 6.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title