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Tbio
MYO10
Unconventional myosin-X

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507288
  • ENSP00000426664
  • ENSG00000145555
  • ENST00000513610
  • ENSP00000421280

Symbol
  • KIAA0799
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
trait
0.99
transcription factor perturbation
0.99
kinase perturbation
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.97   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.97   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999999697
p_ni:  3.02e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999997884
p_ni:  0.000002104
p_wrong:  1.1e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.984
Data Source:  Reactome,STRINGDB
NEO1
Tbio
Novelty:  0.00625858
Score:  0.945
Data Source:  Reactome,STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.926
Data Source:  Reactome,STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.926
Data Source:  STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
Score:  0.926
Data Source:  STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
Score:  0.924
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.923
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.923
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
1
1
24.5
lymphocyte count
2
1
2
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
24.5
lymphocyte count
2
12.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin X
VGNC:13549
471462
Macaque
myosin X
718002
Mouse
MGI:107716
17909
Rat
RGD:1307193
310178
Dog
myosin X
VGNC:43554
489261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin X
Macaque
myosin X
Mouse
Rat
Dog
myosin X
Publication Statistics
PubMed Score 59.97
PubMed score by year
PubTator Score 49.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title