Tchem MYLK4 Myosin light chain kinase family member 4

Protein Summary

Uniprot Accession IDs

• Q86YV6
• A2RUC0
• Q5TAW2

Gene Name

• MYLK4

Ensembl ID

• ENST00000274643
• ENSP00000274643
• ENSG00000145949

Symbol

• SGK085
• SgK085

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
protein domain	0.85
gene perturbation	0.81
microRNA	0.79
tissue sample	0.55

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Mlck Family / Myosin Light Chain Kinase Family Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

sunitinib

MYLK4Tchem Kinase

INHIBITOR pIC50 : 6.96

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

lestaurtinib

MYLK4Tchem Kinase

pKd : 7.57

Protein-Protein Interactions (60)

Explore Interacting Targets

1 – 10 of 60

• See Interactions on String-DB

HSP90AB4P

Tdark

p_int:  0.999998551

p_ni:  0.000001449

Data Source:  BioPlex

HSP90AB3P

Tdark

p_int:  0.999998226

p_ni:  0.000001773

p_wrong:  1e-9

Data Source:  BioPlex

HSP90AA5P

Tdark

p_int:  0.999941458

p_ni:  0.000058539

p_wrong:  4e-9

Data Source:  BioPlex

HSP90AB1

Tchem

Novelty:  0.00907961

p_int:  0.991770218

p_ni:  0.008229782

Score:  0.287

Data Source:  BioPlex,STRINGDB

HSP90AA1

Tchem

Novelty:  0.00016774

p_int:  0.967610273

p_ni:  0.032389727

Score:  0.306

Data Source:  BioPlex,STRINGDB

MYL12A

Tbio

Novelty:  0.00944255

Score:  0.835

Data Source:  STRINGDB

MYL12B

Tbio

Novelty:  0.00999083

Score:  0.834

Data Source:  STRINGDB

MYL9

Tbio

Novelty:  0.00309239

Score:  0.833

Data Source:  STRINGDB

PRKCE

Tchem

Family:  Kinase

Novelty:  0.00890161

Score:  0.804

Data Source:  STRINGDB

MCUR1

Tbio

Novelty:  0.06505266

Score:  0.726

Data Source:  STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (3)

1 – 3 of 3

CALM3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: Oxytocin signaling pathway

2: Gastric acid secretion

3: Calcium signaling pathway

4: Apelin signaling pathway

more:  2 more common pathways

CALM2

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: Oxytocin signaling pathway

2: Gastric acid secretion

3: Calcium signaling pathway

4: Apelin signaling pathway

more:  2 more common pathways

CALM1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: Oxytocin signaling pathway

2: Gastric acid secretion

3: Calcium signaling pathway

4: Apelin signaling pathway

more:  2 more common pathways

Pathways (55)

KEGG (9)

WikiPathways (46)

Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Platelet activation	126 targets	path:hsa04611
KEGG	Focal adhesion	198 targets	path:hsa04510
KEGG	Oxytocin signaling pathway	155 targets	path:hsa04921
KEGG	Gastric acid secretion	78 targets	path:hsa04971
KEGG	Regulation of actin cytoskeleton	212 targets	path:hsa04810

Name	Explore in Pharos	Explore in Source
Platelet activation	126 targets	path:hsa04611
Focal adhesion	198 targets	path:hsa04510
Oxytocin signaling pathway	155 targets	path:hsa04921
Gastric acid secretion	78 targets	path:hsa04971
Regulation of actin cytoskeleton	212 targets	path:hsa04810

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
myosin light chain kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	3		52.7
platelet crit	EFO_0007985	1	1	1		50.6
beta-amyloid 1-42 measurement	EFO_0004670	1	1	1		21.5
malaria	EFO_0001068	1	1	0	2.5	14.2
disease recurrence	EFO_0004952	1	1	0	2.5	14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		52.7
platelet crit	EFO_0007985	1		50.6
beta-amyloid 1-42 measurement	EFO_0004670	1		21.5
malaria	EFO_0001068	0	2.5	14.2
disease recurrence	EFO_0004952	0	2.5	14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
beta-amyloid 1-42 measurement
disease recurrence
heel bone mineral density
intelligence
malaria
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myosin light chain kinase family member 4	VGNC:3499	471840
Macaque	myosin light chain kinase family member 4		707361
Mouse	myosin light chain kinase family, member 4	MGI:3643758	238564
Dog	myosin light chain kinase family member 4		488190
Horse	myosin light chain kinase family member 4 [Source:HGNC Symbol;Acc:HGNC:27972]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myosin light chain kinase family member 4
Macaque	myosin light chain kinase family member 4
Mouse	myosin light chain kinase family, member 4
Dog	myosin light chain kinase family member 4
Horse	myosin light chain kinase family member 4 [Source:HGNC Symbol;Acc:HGNC:27972]

Publication Statistics

PubMed Score 8.27

PubMed score by year

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PubTator Score 1.17

PubTator score by year

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Patents

Patents by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title