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Tbio
MYLIP
E3 ubiquitin-protein ligase MYLIP

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356840
  • ENSP00000349298
  • ENSG00000007944

Symbol
  • BZF1
  • IDOL
  • MIR
  • IDOL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.85
kinase perturbation
0.76
PubMedID
0.75
microRNA
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.24   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.24   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
CTR9
Tbio
Family:  Enzyme
Novelty:  0.04434964
p_int:  0.998095374
p_ni:  0.001904625
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.995791948
p_ni:  0.004203903
p_wrong:  0.000004149
Score:  0.188
Data Source:  BioPlex,STRINGDB
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.965114952
p_ni:  0.034885002
p_wrong:  4.6e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
PAF1
Tbio
Family:  Enzyme
Novelty:  0.00200047
p_int:  0.893712059
p_ni:  0.106287941
p_wrong:  1e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
UBA6
Tchem
Novelty:  0.05213412
p_int:  0.77855158
p_ni:  0.221245962
p_wrong:  0.000202458
Score:  0.92
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.996
Data Source:  STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
Score:  0.983
Data Source:  STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.978
Data Source:  Reactome,STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.976
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Plasma lipoprotein assembly, remodeling, and clearance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
6
13
96.7
total cholesterol measurement
5
3
8
89.3
apolipoprotein B measurement
2
3
3
88.1
HMG CoA reductase inhibitor use measurement
1
1
1
39.6
reticulocyte measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
13
96.7
total cholesterol measurement
8
89.3
apolipoprotein B measurement
3
88.1
HMG CoA reductase inhibitor use measurement
1
39.6
reticulocyte measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin regulatory light chain interacting protein
VGNC:3498
462452
Macaque
myosin regulatory light chain interacting protein
702625
Mouse
MGI:2388271
218203
Rat
RGD:1305761
306825
Dog
myosin regulatory light chain interacting protein
VGNC:43548
488230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin regulatory light chain interacting protein
Macaque
myosin regulatory light chain interacting protein
Mouse
Rat
Dog
myosin regulatory light chain interacting protein
Publication Statistics
PubMed Score 130.24
PubMed score by year
PubTator Score 146.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title