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Tbio
MYL6
Myosin light polypeptide 6

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547649
  • ENSP00000446714
  • ENSG00000092841
  • ENST00000548293
  • ENSP00000448101
  • ENST00000550697
  • ENSP00000446955

Symbol
  • LC17
  • ESMLC
  • LC17A
  • LC17B
  • MLC-3
  • MLC1SM
  • MLC3NM
  • MLC3SM
  • LC17-GI
  • LC17-NM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.98
hub protein
0.96
transcription factor perturbation
0.88
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.999999963
p_ni:  7e-9
p_wrong:  3.1e-8
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.999996971
p_ni:  0.000003029
Score:  0.429
Data Source:  BioPlex,STRINGDB
IQGAP1
Tbio
Family:  Enzyme
Novelty:  0.00434481
p_int:  0.999964664
p_ni:  0.000035337
Score:  0.383
Data Source:  BioPlex,STRINGDB
SRBD1
Tbio
Novelty:  0.18931356
p_int:  0.999742718
p_ni:  0.000257282
p_wrong:  1e-9
Data Source:  BioPlex
MYH14
Tchem
Novelty:  0.00874871
p_int:  0.999636342
p_ni:  0.000363659
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
p_int:  0.992718955
p_ni:  0.007281046
Score:  0.946
Data Source:  BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.985829132
p_ni:  0.014164697
p_wrong:  0.000006171
Score:  0.173
Data Source:  BioPlex,STRINGDB
TRAPPC8
Tdark
Novelty:  0.07711264
p_int:  0.977987019
p_ni:  0.022012981
Data Source:  BioPlex
LIMA1
Tbio
Novelty:  0.02718476
p_int:  0.967270923
p_ni:  0.032729077
Score:  0.394
Data Source:  BioPlex,STRINGDB
MYH9
Tbio
Novelty:  0.0016488
p_int:  0.963396762
p_ni:  0.036603238
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 5 of 5
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
Muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
5
5
97.2
3
2
0
1.3
89.2
mathematical ability
2
2
2
82.9
body mass index
3
2
3
75
2
2
0
1.2
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
97.2
0
1.3
89.2
mathematical ability
2
82.9
body mass index
3
75
0
1.2
73.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 6
VGNC:5495
746313
Macaque
myosin light chain 6
711889
Mouse
MGI:109318
17904
Rat
RGD:1589019
685867
Horse
myosin light chain 6
VGNC:49494
100052035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 6
Macaque
myosin light chain 6
Mouse
Rat
Horse
myosin light chain 6
Publication Statistics
PubMed Score 152.90
PubMed score by year
PubTator Score 27.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title