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Tbio
MYL3
Myosin light chain 3

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292327
  • ENSP00000292327
  • ENSG00000160808
  • ENST00000395869
  • ENSP00000379210

Symbol
  • CMH8
  • VLC1
  • VLCl
  • MLC1V
  • MLC1SB
  • MLC-lV/sb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
gene perturbation
0.7
cellular component
0.62
PubMedID
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.95   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.95   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
MYH10
Tchem
Novelty:  0.00624251
p_int:  0.997686011
p_ni:  0.002313989
Score:  0.963
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.993892866
p_ni:  0.006107134
Score:  0.473
Data Source:  BioPlex,STRINGDB
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.986768886
p_ni:  4.7e-8
p_wrong:  0.013231068
Data Source:  BioPlex
IQGAP1
Tbio
Family:  Enzyme
Novelty:  0.00434481
p_int:  0.985699718
p_ni:  0.014300281
Score:  0.322
Data Source:  BioPlex,STRINGDB
MYH14
Tchem
Novelty:  0.00874871
p_int:  0.984588129
p_ni:  0.015411871
Score:  0.959
Data Source:  BioPlex,STRINGDB
MYH9
Tbio
Novelty:  0.0016488
p_int:  0.95227448
p_ni:  0.04772552
Score:  0.96
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
Score:  0.996
Data Source:  STRINGDB
MYL2
Tbio
Novelty:  0.0018887
Score:  0.991
Data Source:  Reactome,STRINGDB
MYH6
Tbio
Novelty:  0.00058671
Score:  0.99
Data Source:  Reactome,STRINGDB
TNNI3
Tbio
Novelty:  0.00020053
Score:  0.985
Data Source:  STRINGDB
Pathways (142)
Muscle contraction (R-HSA-397014)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
4
5
85.6
BMI-adjusted waist-hip ratio
1
4
4
84.8
body height
1
1
1
73.9
sex hormone-binding globulin measurement
2
1
2
71.5
urinary albumin to creatinine ratio
3
2
3
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
85.6
BMI-adjusted waist-hip ratio
4
84.8
body height
1
73.9
sex hormone-binding globulin measurement
2
71.5
urinary albumin to creatinine ratio
3
63.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 3
VGNC:11988
460327
Macaque
myosin light chain 3
712209
Mouse
MGI:97268
17897
Rat
RGD:3142
24585
Dog
myosin light chain 3
VGNC:43544
476644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 3
Macaque
myosin light chain 3
Mouse
Rat
Dog
myosin light chain 3
Publication Statistics
PubMed Score 181.95
PubMed score by year
PubTator Score 61.71
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title