Tbio MYL2 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Protein Summary

Description

Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P10916
• Q16123
• MLC-2

Gene Name

• MYL2

Ensembl ID

• ENST00000228841
• ENSP00000228841
• ENSG00000111245

Symbol

• MLC2
• MLC2
• CMH10
• MLC-2s/v

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
gene perturbation	0.63
pathway	0.6
tissue	0.6
disease	0.59

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Myosin Regulatory Light Chain 2, Ventricular/cardiac Muscle Isoform

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Regulatory Light Chain 2, Ventricular/cardiac Muscle Isoform

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Regulatory Light Chain 2, Ventricular/cardiac Muscle Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 531.95   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 343   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 531.95   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0