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Tbio
MYL1
Myosin light chain 1/3, skeletal muscle isoform

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341685
  • ENSP00000343321
  • ENSG00000168530
  • ENST00000352451
  • ENSP00000307280

Symbol
  • MLC1F
  • MLC3F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.69
cell type or tissue
0.61
cell line
0.59
cellular component
0.54
interacting protein
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.53   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.53   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
RBMX2
Tbio
Novelty:  0.08867468
p_int:  0.997730886
p_ni:  0.000003074
p_wrong:  0.00226604
Data Source:  BioPlex
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.997513101
p_ni:  1.4e-8
p_wrong:  0.002486885
Score:  0.214
Data Source:  BioPlex,STRINGDB
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.995419913
p_ni:  0.000001346
p_wrong:  0.004578741
Data Source:  BioPlex
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
p_int:  0.978943081
p_ni:  0.000001495
p_wrong:  0.021055424
Score:  0.347
Data Source:  BioPlex,STRINGDB
NEB
Tbio
Novelty:  0.00174728
Score:  0.996
Data Source:  STRINGDB
TNNT3
Tbio
Novelty:  0.0212335
Score:  0.995
Data Source:  STRINGDB
TNNI2
Tbio
Novelty:  0.02772952
Score:  0.995
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.994
Data Source:  Reactome,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.993
Data Source:  STRINGDB
MYH8
Tbio
Novelty:  0.01020559
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
3
97.9
serum metabolite measurement
2
3
3
96.5
urinary metabolite measurement
2
2
2
96.4
metabolite measurement
1
1
1
95.4
acylcarnitine measurement
1
1
1
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
97.9
serum metabolite measurement
3
96.5
urinary metabolite measurement
2
96.4
metabolite measurement
1
95.4
acylcarnitine measurement
1
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 1
VGNC:2050
459915
Mouse
MGI:97269
17901
Rat
RGD:1598796
56781
Dog
myosin light chain 1
VGNC:43541
478896
Horse
myosin light chain 1
VGNC:20482
100052501
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 1
Mouse
Rat
Dog
myosin light chain 1
Horse
myosin light chain 1
Publication Statistics
PubMed Score 268.53
PubMed score by year
PubTator Score 61.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title