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Tbio
MYH8
Myosin-8

Protein Summary
Description
Muscle contraction. Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403437
  • ENSP00000384330
  • ENSG00000133020

Symbol
  • DA7
  • MyHC-pn
  • gtMHC-F
  • MyHC-peri
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.98
protein domain
0.85
cell type or tissue
0.7
cellular component
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999999983
p_ni:  1.7e-8
Data Source:  BioPlex
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999999967
p_ni:  2e-9
p_wrong:  3.1e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999999957
p_ni:  4.3e-8
Data Source:  BioPlex
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999999953
p_ni:  4.7e-8
Data Source:  BioPlex
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999994977
p_ni:  0.000005023
Data Source:  BioPlex
AURKC
Tchem
Family:  Kinase
Novelty:  0.00950433
p_int:  0.999992659
p_ni:  0.000007341
Score:  0.313
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999979525
p_ni:  0.000020224
p_wrong:  2.51e-7
Data Source:  BioPlex
ROGDI
Tbio
Novelty:  0.077277
p_int:  0.996964407
p_ni:  0.000093057
p_wrong:  0.002942536
Score:  0.261
Data Source:  BioPlex,STRINGDB
KLHL9
Tdark
Novelty:  0.22434722
p_int:  0.943151646
p_ni:  0.056847357
p_wrong:  9.97e-7
Data Source:  BioPlex
TPM1
Tbio
Novelty:  0.00261206
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Muscle contraction (R-HSA-397014)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 8
VGNC:12482
455074
Mouse
MGI:1339712
17885
Dog
myosin heavy chain 8
VGNC:49929
403808
Cow
myosin heavy chain 8
VGNC:31797
281339
Xenopus
myosin, heavy chain 3, skeletal muscle, embryonic
XB-GENE-989276
448762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 8
Mouse
Dog
myosin heavy chain 8
Cow
myosin heavy chain 8
Xenopus
myosin, heavy chain 3, skeletal muscle, embryonic
Publication Statistics
PubMed Score 84.02
PubMed score by year
PubTator Score 20.78
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title