Protein Summary
Involved in muscle contraction. The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
- ENST00000262873
- ENSP00000262873
- ENSG00000078814
- KIAA1512
- MHC14
- MYH14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.94 | ||
protein domain | 0.85 | ||
histone modification site profile | 0.79 | ||
transcription factor | 0.7 | ||
transcription factor binding site profile | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.87 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 37 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.87 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 37 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (143)
LRRCC1
Novelty: 0.14730953
p_int: 0.99999726
p_ni: 8.2e-8
p_wrong: 0.000002659
Score: 0.365
Data Source: BioPlex,STRINGDB
HSPA8
Novelty: 0.00081014
p_int: 0.840576616
p_ni: 0.159423385
Score: 0.153
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
KEGG (1)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Tight junction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Tight junction | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (3)
Components (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 2 | 5 | 91.9 | |||||
suntan | 1 | 2 | 2 | 89.6 | |||||
glomerular filtration rate | 2 | 1 | 1 | 8.6 | 83.3 | ||||
heel bone mineral density | 2 | 1 | 2 | 77.6 | |||||
electrocardiography | 1 | 1 | 41 | 75.5 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 5 | 91.9 | |||||
suntan | 2 | 89.6 | |||||
glomerular filtration rate | 1 | 8.6 | 83.3 | ||||
heel bone mineral density | 2 | 77.6 | |||||
electrocardiography | 41 | 75.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 7B | VGNC:14262 | 745207 | |||||
Macaque | myosin heavy chain 7B | 712230 | ||||||
Mouse | MGI:3710243 | 668940 | ||||||
Rat | RGD:1307994 | 311570 | ||||||
Dog | myosin heavy chain 7B | VGNC:43539 | 477206 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 7B | |||||
Macaque | myosin heavy chain 7B | |||||
Mouse | ||||||
Rat | ||||||
Dog | myosin heavy chain 7B | |||||
Publication Statistics
PubMed Score 102.87
PubMed score by year
PubTator Score 7.06
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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