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Tbio
MYH3
Myosin-3

Protein Summary
Description
Muscle contraction. Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000583535
  • ENSP00000464317
  • ENSG00000109063

Symbol
  • DA8
  • DA2A
  • DA2B
  • HEMHC
  • SMHCE
  • MYHSE1
  • MYHC-EMB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
cell type or tissue
0.7
cellular component
0.67
gene perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.98   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.98   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999999994
p_ni:  5e-9
Data Source:  BioPlex
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999999993
p_ni:  1e-9
p_wrong:  6e-9
Data Source:  BioPlex
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
p_int:  0.999999922
p_ni:  7.7e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
SIX1
Tbio
Family:  TF
Novelty:  0.00415613
p_int:  0.999979924
p_ni:  0.000020026
p_wrong:  4.9e-8
Score:  0.494
Data Source:  BioPlex,STRINGDB
TMEM260
Tdark
Novelty:  0.31409768
p_int:  0.999955511
p_ni:  0.000044376
p_wrong:  1.13e-7
Score:  0.345
Data Source:  BioPlex,STRINGDB
CDCA8
Tbio
Novelty:  0.01448513
p_int:  0.999569486
p_ni:  0.000409041
p_wrong:  0.000021473
Score:  0.207
Data Source:  BioPlex,STRINGDB
TNNI1
Tbio
Novelty:  0.01639536
Score:  0.997
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.996
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.994
Data Source:  STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.983
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1339709
17883
Rat
RGD:3138
24583
Dog
myosin heavy chain 3
VGNC:53030
489504
Horse
myosin heavy chain 3
VGNC:20480
100063003
Cow
myosin heavy chain 3
VGNC:53031
281338
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
myosin heavy chain 3
Horse
myosin heavy chain 3
Cow
myosin heavy chain 3
Publication Statistics
PubMed Score 172.98
PubMed score by year
PubTator Score 38.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title