Protein Summary
Muscle contraction. Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
- ENST00000583535
- ENSP00000464317
- ENSG00000109063
- DA8
- DA2A
- DA2B
- HEMHC
- SMHCE
- MYHSE1
- MYHC-EMB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.99 | ||
protein domain | 0.85 | ||
cell type or tissue | 0.7 | ||
cellular component | 0.67 | ||
gene perturbation | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.98 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 96 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.98 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 96 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (141)
HIF1A
Family: TF
Novelty: 0.00011503
p_int: 0.999999922
p_ni: 7.7e-8
Score: 0.278
Data Source: BioPlex,STRINGDB
SIX1
Family: TF
Novelty: 0.00415613
p_int: 0.999979924
p_ni: 0.000020026
p_wrong: 4.9e-8
Score: 0.494
Data Source: BioPlex,STRINGDB
TMEM260
Novelty: 0.31409768
p_int: 0.999955511
p_ni: 0.000044376
p_wrong: 1.13e-7
Score: 0.345
Data Source: BioPlex,STRINGDB
CDCA8
Novelty: 0.01448513
p_int: 0.999569486
p_ni: 0.000409041
p_wrong: 0.000021473
Score: 0.207
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (2)
KEGG (1)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Muscle contraction | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (6)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1339709 | 17883 | ||||||
Rat | RGD:3138 | 24583 | ||||||
Dog | myosin heavy chain 3 | VGNC:53030 | 489504 | |||||
Horse | myosin heavy chain 3 | VGNC:20480 | 100063003 | |||||
Cow | myosin heavy chain 3 | VGNC:53031 | 281338 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | myosin heavy chain 3 | |||||
Horse | myosin heavy chain 3 | |||||
Cow | myosin heavy chain 3 | |||||
Publication Statistics
PubMed Score 172.98
PubMed score by year
PubTator Score 38.58
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
---|