Tbio MYH3 Myosin-3

Protein Summary

Description

Muscle contraction. Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11055
• Q15492

Gene Name

• MYH3

Ensembl ID

• ENST00000583535
• ENSP00000464317
• ENSG00000109063

Symbol

• DA8
• DA2A
• DA2B
• HEMHC
• SMHCE
• MYHSE1
• MYHC-EMB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.85
cell type or tissue	0.7
cellular component	0.67
gene perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.98   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.98   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (141)

Explore Interacting Targets

1 – 10 of 141

• See Interactions on String-DB

ABTB2

Tdark

Novelty:  0.45729157

p_int:  0.999999994

p_ni:  5e-9

Data Source:  BioPlex

TLE3

Tbio

Novelty:  0.02641884

p_int:  0.999999993

p_ni:  1e-9

p_wrong:  6e-9

Data Source:  BioPlex

HIF1A

Tchem

Family:  TF

Novelty:  0.00011503

p_int:  0.999999922

p_ni:  7.7e-8

Score:  0.278

Data Source:  BioPlex,STRINGDB

SIX1

Tbio

Family:  TF

Novelty:  0.00415613

p_int:  0.999979924

p_ni:  0.000020026

p_wrong:  4.9e-8

Score:  0.494

Data Source:  BioPlex,STRINGDB

TMEM260

Tdark

Novelty:  0.31409768

p_int:  0.999955511

p_ni:  0.000044376

p_wrong:  1.13e-7

Score:  0.345

Data Source:  BioPlex,STRINGDB

CDCA8

Tbio

Novelty:  0.01448513

p_int:  0.999569486

p_ni:  0.000409041

p_wrong:  0.000021473

Score:  0.207

Data Source:  BioPlex,STRINGDB

TNNI1

Tbio

Novelty:  0.01639536

Score:  0.997

Data Source:  STRINGDB

ACTN2

Tbio

Novelty:  0.00615882

Score:  0.996

Data Source:  STRINGDB

TPM2

Tbio

Novelty:  0.00406572

Score:  0.994

Data Source:  STRINGDB

MYL1

Tbio

Novelty:  0.00360262

Score:  0.983

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (2)

KEGG (1)

PathwayCommons (3)

WikiPathways (1)

Muscle contraction (R-HSA-397014)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (6)

Components (5)

Processes (8)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
ATPase activity, coupled	Inferred from Mutant Phenotype (IMP)	BHF-UCL
microfilament motor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
myosin phosphatase activity	Traceable Author Statement (TAS)	Reactome
calmodulin binding	Non-traceable Author Statement (NAS)	BHF-UCL
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
ATP-binding
Calmodulin-binding
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Methylation
Motor protein
Muscle protein

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	myosin, heavy polypeptide 3, skeletal muscle, embryonic	MGI:1339709	17883
Rat	myosin heavy chain 3	RGD:3138	24583
Dog	myosin heavy chain 3	VGNC:53030	489504
Horse	myosin heavy chain 3	VGNC:20480	100063003
Cow	myosin heavy chain 3	VGNC:53031	281338

Species	Name	OMA	EggNOG	Inparanoid
Mouse	myosin, heavy polypeptide 3, skeletal muscle, embryonic
Rat	myosin heavy chain 3
Dog	myosin heavy chain 3
Horse	myosin heavy chain 3
Cow	myosin heavy chain 3

Publication Statistics

PubMed Score 172.98

PubMed score by year

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PubTator Score 38.58

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (18)

Items per page:

10

0 of 0

PMID	Year	Title