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Tchem
MYH14
Myosin-14

Protein Summary
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376970
  • ENSP00000366169
  • ENSG00000105357
  • ENST00000425460
  • ENSP00000407879
  • ENST00000596571
  • ENSP00000472819
  • ENST00000598205
  • ENSP00000472543
  • ENST00000601313
  • ENSP00000470298
  • ENST00000642316
  • ENSP00000493594

Symbol
  • KIAA2034
  • DFNA4
  • MHC16
  • MYH17
  • PNMHH
  • DFNA4A
  • myosin
  • FP17425
  • NMHC II-C
  • NMHC-II-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.95
cellular component
0.79
protein domain
0.73
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.05   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.05   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.999919198
p_ni:  0.000080802
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999726321
p_ni:  0.000273679
Score:  0.155
Data Source:  BioPlex,STRINGDB
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.999636342
p_ni:  0.000363659
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
MYL3
Tbio
Novelty:  0.00493817
p_int:  0.984588129
p_ni:  0.015411871
Score:  0.959
Data Source:  BioPlex,STRINGDB
UNC45A
Tbio
Novelty:  0.07503761
p_int:  0.942855458
p_ni:  0.057144542
Score:  0.655
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.897727394
p_ni:  0.102272606
Data Source:  BioPlex
MYL9
Tbio
Novelty:  0.00309239
Score:  0.983
Data Source:  Reactome,STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.952
Data Source:  Reactome,STRINGDB
MYL5
Tbio
Novelty:  0.012802
Score:  0.95
Data Source:  STRINGDB
MYL6B
Tbio
Novelty:  0.01292785
Score:  0.947
Data Source:  STRINGDB
Pathways (19)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
RHO GTPase Effectors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platinum measurement
1
1
1
14.2
response to cisplatin
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platinum measurement
1
14.2
response to cisplatin
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 14
VGNC:13233
468959
Macaque
myosin heavy chain 14
719560
Mouse
MGI:1919210
71960
Rat
RGD:1306821
308572
Dog
myosin heavy chain 14
VGNC:43538
100688336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 14
Macaque
myosin heavy chain 14
Mouse
Rat
Dog
myosin heavy chain 14
Publication Statistics
PubMed Score 104.05
PubMed score by year
PubTator Score 8606.95
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title