Tbio MYH11 Myosin-11

Protein Summary

Description

Muscle contraction. The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35749
• D2JYH7
• O00396
• O94944
• P78422
• Q3MIV8
• Q3MNF0
• Q3MNF1

Gene Name

• MYH11

Ensembl ID

• ENST00000300036
• ENSP00000300036
• ENSG00000133392
• ENST00000396324
• ENSP00000379616
• ENST00000452625
• ENSP00000407821
• ENST00000576790
• ENSP00000458731
• ENST00000612165
• ENSP00000478092
• ENSG00000276480
• ENST00000616422
• ENSP00000478816
• ENST00000621545
• ENSP00000478109
• ENST00000634050
• ENSP00000488461

Symbol

• KIAA0866
• AAT4
• FAA4
• SMHC
• SMMHC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
kinase perturbation	0.97
protein domain	0.92
cellular component	0.78
protein complex	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.69   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 655   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.69   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (217)

Explore Interacting Targets

1 – 10 of 217

• See Interactions on String-DB

MYL6

Tbio

Novelty:  0.00594485

p_int:  0.999999963

p_ni:  7e-9

p_wrong:  3.1e-8

Score:  0.978

Data Source:  BioPlex,Reactome,STRINGDB

PSMD3

Tbio

Family:  Enzyme

Novelty:  0.03106272

p_int:  0.999999222

p_ni:  7.77e-7

Data Source:  BioPlex

RWDD2B

Tdark

Novelty:  0.42452529

p_int:  0.999996185

p_ni:  0.000003809

p_wrong:  6e-9

Score:  0.214

Data Source:  BioPlex,STRINGDB

MPP1

Tbio

Novelty:  0.08674817

p_int:  0.999982472

p_ni:  0.000017521

p_wrong:  8e-9

Score:  0.41

Data Source:  BioPlex,STRINGDB

OVCA2

Tbio

Novelty:  0.1210116

p_int:  0.999944126

p_ni:  0.000032861

p_wrong:  0.000023013

Score:  0.548

Data Source:  BioPlex,STRINGDB

GDF9

Tbio

Novelty:  0.00258351

p_int:  0.999937249

p_ni:  0.000029226

p_wrong:  0.000033526

Score:  0.227

Data Source:  BioPlex,STRINGDB

SLC9A8

Tbio

Family:  Transporter

Novelty:  0.03305341

p_int:  0.997023228

p_ni:  0.000179549

p_wrong:  0.002797223

Data Source:  BioPlex

ACTA2

Tbio

Novelty:  0.00199354

Score:  0.993

Data Source:  STRINGDB

ACTG2

Tbio

Novelty:  0.00304944

Score:  0.986

Data Source:  STRINGDB

MYL12B

Tbio

Novelty:  0.00999083

Score:  0.985

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Upstream (1)

1 – 1 of 1

PRKCD

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Vascular smooth muscle contraction

Pathways (21)

Reactome (16)

KEGG (2)

PathwayCommons (3)

Axon guidance (R-HSA-422475)

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Find Similar Targets

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5

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHA-mediated growth cone collapse	15 targets	R-HSA-3928663
Reactome	Muscle contraction	202 targets	R-HSA-397014

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHA-mediated growth cone collapse	15 targets	R-HSA-3928663
Muscle contraction	202 targets	R-HSA-397014

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (5)

Processes (5)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
structural constituent of muscle	Inferred from Mutant Phenotype (IMP)	UniProtKB
actin filament binding	Inferred from Electronic Annotation (IEA)	InterPro
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
motor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (22)

Items per page:

5

1 – 5 of 22

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	ENSG00000133392	1	1	1		35
HbA1c measurement	EFO_0004541	ENSG00000276480	1	1	1		35
mean platelet volume	EFO_0004584	ENSG00000133392	1	1	1		33.1
mean platelet volume	EFO_0004584	ENSG00000276480	1	1	1		33.1
skin aging measurement	EFO_0008006	ENSG00000133392	1	1	1		29

Items per page:

5

1 – 5 of 22

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1		35
HbA1c measurement	EFO_0004541	1		35
mean platelet volume	EFO_0004584	1		33.1
mean platelet volume	EFO_0004584	1		33.1
skin aging measurement	EFO_0008006	1		29

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Alternative splicing
Aortic aneurysm
ATP-binding
Calmodulin-binding
Chromosomal rearrangement
Coiled coil
Complete proteome
Disease mutation
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
coronary artery disease
electrocardiography
HbA1c measurement
inflammatory biomarker measurement
intelligence
mean platelet volume
multiple myeloma
overall survival
schizophrenia
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
muscle phenotype
renal/urinary system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myosin heavy chain 11	VGNC:51223	453949
Macaque	myosin heavy chain 11		713882
Mouse	myosin, heavy polypeptide 11, smooth muscle	MGI:102643	17880
Dog	myosin heavy chain 11	VGNC:43536	479836
Horse	myosin heavy chain 11	VGNC:20478	100050346

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myosin heavy chain 11
Macaque	myosin heavy chain 11
Mouse	myosin, heavy polypeptide 11, smooth muscle
Dog	myosin heavy chain 11
Horse	myosin heavy chain 11

Publication Statistics

PubMed Score 699.69

PubMed score by year

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PubTator Score 215.85

PubTator score by year

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Related Publications

Text Mined References (59)

GeneRif Annotations (39)

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PMID	Year	Title