Tbio MYH11 Myosin-11

Protein Summary

Description

Muscle contraction. The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35749
• D2JYH7
• O00396
• O94944
• P78422
• Q3MIV8
• Q3MNF0
• Q3MNF1

Gene Name

• MYH11

Ensembl ID

• ENST00000300036
• ENSP00000300036
• ENSG00000133392
• ENST00000396324
• ENSP00000379616
• ENST00000452625
• ENSP00000407821
• ENST00000576790
• ENSP00000458731
• ENST00000612165
• ENSP00000478092
• ENSG00000276480
• ENST00000616422
• ENSP00000478816
• ENST00000621545
• ENSP00000478109
• ENST00000634050
• ENSP00000488461

Symbol

• KIAA0866
• AAT4
• FAA4
• SMHC
• SMMHC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
kinase perturbation	0.97
protein domain	0.92
cellular component	0.78
protein complex	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.22   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 655   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.22   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0