Protein Summary
Muscle contraction. The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, wit ...more
- ENST00000300036
- ENSP00000300036
- ENSG00000133392
- ENST00000396324
- ENSP00000379616
- ENST00000452625
- ENSP00000407821
- ENST00000576790
- ENSP00000458731
- ENST00000612165
- ENSP00000478092
- ENSG00000276480
- ENST00000616422
- ENSP00000478816
- ENST00000621545
- ENSP00000478109
- ENST00000634050
- ENSP00000488461
- KIAA0866
- AAT4
- FAA4
- SMHC
- SMMHC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
kinase perturbation | 0.97 | ||
protein domain | 0.92 | ||
cellular component | 0.78 | ||
protein complex | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.69 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 655 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.69 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 655 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (217)
MYL6
Novelty: 0.00594485
p_int: 0.999999963
p_ni: 7e-9
p_wrong: 3.1e-8
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
RWDD2B
Novelty: 0.42452529
p_int: 0.999996185
p_ni: 0.000003809
p_wrong: 6e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
MPP1
Novelty: 0.08674817
p_int: 0.999982472
p_ni: 0.000017521
p_wrong: 8e-9
Score: 0.41
Data Source: BioPlex,STRINGDB
OVCA2
Novelty: 0.1210116
p_int: 0.999944126
p_ni: 0.000032861
p_wrong: 0.000023013
Score: 0.548
Data Source: BioPlex,STRINGDB
GDF9
Novelty: 0.00258351
p_int: 0.999937249
p_ni: 0.000029226
p_wrong: 0.000033526
Score: 0.227
Data Source: BioPlex,STRINGDB
SLC9A8
Family: Transporter
Novelty: 0.03305341
p_int: 0.997023228
p_ni: 0.000179549
p_wrong: 0.002797223
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (21)
Reactome (16)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHA-mediated growth cone collapse | ||||
Reactome | Muscle contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHA-mediated growth cone collapse | ||||
Muscle contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (5)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 1 | 1 | 35 | ||||||
HbA1c measurement | 1 | 1 | 1 | 35 | ||||||
mean platelet volume | 1 | 1 | 1 | 33.1 | ||||||
mean platelet volume | 1 | 1 | 1 | 33.1 | ||||||
skin aging measurement | 1 | 1 | 1 | 29 | ||||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 35 | |||||
HbA1c measurement | 1 | 35 | |||||
mean platelet volume | 1 | 33.1 | |||||
mean platelet volume | 1 | 33.1 | |||||
skin aging measurement | 1 | 29 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 11 | VGNC:51223 | 453949 | |||||
Macaque | myosin heavy chain 11 | 713882 | ||||||
Mouse | MGI:102643 | 17880 | ||||||
Dog | myosin heavy chain 11 | VGNC:43536 | 479836 | |||||
Horse | myosin heavy chain 11 | VGNC:20478 | 100050346 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | myosin heavy chain 11 | |||||
Macaque | myosin heavy chain 11 | |||||
Mouse | ||||||
Dog | myosin heavy chain 11 | |||||
Horse | myosin heavy chain 11 | |||||
Publication Statistics
PubMed Score 699.69
PubMed score by year
PubTator Score 215.85
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
---|