Protein Summary
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSe ...more
- ENST00000269243
- ENSP00000269243
- ENSG00000133026
- ENST00000360416
- ENSP00000353590
- ENST00000379980
- ENSP00000369315
- NMMHCB
- NMMHC-IIB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.99 | ||
interacting protein | 0.99 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.94 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 143.84 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 143.84 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 38
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (259)
MYL12B
Novelty: 0.00999083
p_int: 0.999788869
p_ni: 0.000211132
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
MYL3
Novelty: 0.00493817
p_int: 0.997686011
p_ni: 0.002313989
Score: 0.963
Data Source: BioPlex,STRINGDB
MYL6
Novelty: 0.00594485
p_int: 0.940227121
p_ni: 0.05977288
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (20)
Reactome (14)
KEGG (2)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHA-mediated growth cone collapse | ||||
Reactome | RHO GTPase Effectors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHA-mediated growth cone collapse | ||||
RHO GTPase Effectors | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (10)
Components (21)
Processes (28)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 1 | 2 | 17.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 17.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 10 | VGNC:12476 | 455090 | |||||
Mouse | MGI:1930780 | 77579 | ||||||
Rat | RGD:71000 | 79433 | ||||||
Dog | myosin heavy chain 10 | VGNC:43535 | 479497 | |||||
Horse | myosin heavy chain 10 | VGNC:20477 | 100062708 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | myosin heavy chain 10 | |||||
Horse | myosin heavy chain 10 | |||||
Publication Statistics
PubMed Score 143.84
PubMed score by year
PubTator Score 47.13
PubTator score by year
Related Publications
Text Mined References (69)
GeneRif Annotations (45)
Items per page:
0 of 0
PMID | Year | Title |
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