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Tbio
MYH1
Myosin-1

Protein Summary
Description
Muscle contraction. Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226207
  • ENSP00000226207
  • ENSG00000109061

Symbol
  • MYHa
  • HEL71
  • MYHSA1
  • MyHC-2x
  • MyHC-2X/D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.95
protein domain
0.85
cellular component
0.79
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.86   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.86   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
TLE3
Tbio
Novelty:  0.02641884
p_int:  1
Score:  0.21
Data Source:  BioPlex,STRINGDB
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999999999
p_ni:  1e-9
Data Source:  BioPlex
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999999999
p_ni:  1e-9
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
p_int:  0.999999942
p_ni:  5.7e-8
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999996979
p_ni:  0.000003021
Data Source:  BioPlex
AURKC
Tchem
Family:  Kinase
Novelty:  0.00950433
p_int:  0.999974673
p_ni:  0.000025321
p_wrong:  6e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
TMEM260
Tdark
Novelty:  0.31409768
p_int:  0.999968323
p_ni:  0.00003043
p_wrong:  0.000001247
Score:  0.309
Data Source:  BioPlex,STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.982
Data Source:  STRINGDB
MYLPF
Tbio
Novelty:  0.00960325
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin-8
745774
Mouse
MGI:1339711
17879
Horse
myosin, heavy chain 1, skeletal muscle, adult
791235
Cow
myosin, heavy chain 1, skeletal muscle, adult
281337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin-8
Mouse
Horse
myosin, heavy chain 1, skeletal muscle, adult
Cow
myosin, heavy chain 1, skeletal muscle, adult
Publication Statistics
PubMed Score 180.86
PubMed score by year
PubTator Score 40.50
PubTator score by year
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Related Publications
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PMID
Year
Title