Protein Summary
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
- ENST00000228641
- ENSP00000228641
- ENSG00000111046
- BHLHC4
- MRF4
- CNM3
- MRF4
- myf-6
- bHLHc4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.9 | ||
molecular function | 0.84 | ||
gene perturbation | 0.82 | ||
cellular component | 0.53 | ||
cell line | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.11 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.11 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (82)
TCF4
Family: TF
Novelty: 0.0019718
p_int: 0.999999942
p_ni: 5.8e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
TCF12
Family: TF
Novelty: 0.00381424
p_int: 0.999999926
p_ni: 7.4e-8
Score: 0.979
Data Source: BioPlex,STRINGDB
TCF3
Family: TF
Novelty: 0.00112675
p_int: 0.99999991
p_ni: 9e-8
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
NES
Novelty: 0.00035379
p_int: 0.999989783
p_ni: 0.000010217
Score: 0.706
Data Source: BioPlex,STRINGDB
ID4
Family: TF
Novelty: 0.00399089
p_int: 0.999896469
p_ni: 0.000100174
p_wrong: 0.000003357
Score: 0.729
Data Source: BioPlex,STRINGDB
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.999390132
p_ni: 0.000609868
Score: 0.923
Data Source: BioPlex,STRINGDB
IRGC
Family: Enzyme
Novelty: 0.10743948
p_int: 0.996994194
p_ni: 0.003005801
p_wrong: 5e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
TBC1D4
Novelty: 0.00549202
p_int: 0.956321185
p_ni: 0.043678815
Score: 0.186
Data Source: BioPlex,STRINGDB
DISC1
Novelty: 0.00183442
p_int: 0.941832052
p_ni: 0.058165018
p_wrong: 0.00000293
Score: 0.177
Data Source: BioPlex,STRINGDB
KAT14
Novelty: 0.17168043
p_int: 0.925933178
p_ni: 0.074066815
p_wrong: 6e-9
Score: 0.305
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (2)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Myogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Myogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (6)
Components (3)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | myogenic factor 6 | VGNC:5494 | 745321 | |||||
Macaque | myogenic factor 6 | 697306 | ||||||
Mouse | MGI:97253 | 17878 | ||||||
Rat | RGD:3134 | 25714 | ||||||
Dog | myogenic factor 6 | VGNC:43534 | 611531 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | myogenic factor 6 | |||||
Macaque | myogenic factor 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | myogenic factor 6 | |||||
Publication Statistics
PubMed Score 167.11
PubMed score by year
PubTator Score 60.19
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (3)
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PMID | Year | Title |
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