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Tbio
MYF6
Myogenic factor 6

Protein Summary
Description
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228641
  • ENSP00000228641
  • ENSG00000111046

Symbol
  • BHLHC4
  • MRF4
  • CNM3
  • MRF4
  • myf-6
  • bHLHc4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
molecular function
0.84
gene perturbation
0.82
cellular component
0.53
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999942
p_ni:  5.8e-8
Score:  0.981
Data Source:  BioPlex,STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999999926
p_ni:  7.4e-8
Score:  0.979
Data Source:  BioPlex,STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
p_int:  0.99999991
p_ni:  9e-8
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
NES
Tbio
Novelty:  0.00035379
p_int:  0.999989783
p_ni:  0.000010217
Score:  0.706
Data Source:  BioPlex,STRINGDB
ID4
Tbio
Family:  TF
Novelty:  0.00399089
p_int:  0.999896469
p_ni:  0.000100174
p_wrong:  0.000003357
Score:  0.729
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999390132
p_ni:  0.000609868
Score:  0.923
Data Source:  BioPlex,STRINGDB
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.996994194
p_ni:  0.003005801
p_wrong:  5e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TBC1D4
Tbio
Novelty:  0.00549202
p_int:  0.956321185
p_ni:  0.043678815
Score:  0.186
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.941832052
p_ni:  0.058165018
p_wrong:  0.00000293
Score:  0.177
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.925933178
p_ni:  0.074066815
p_wrong:  6e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myogenic factor 6
VGNC:5494
745321
Macaque
myogenic factor 6
697306
Mouse
MGI:97253
17878
Rat
RGD:3134
25714
Dog
myogenic factor 6
VGNC:43534
611531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myogenic factor 6
Macaque
myogenic factor 6
Mouse
Rat
Dog
myogenic factor 6
Publication Statistics
PubMed Score 167.11
PubMed score by year
PubTator Score 60.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title