Pharos : Target Details

Tbio

Protein Summary

Description

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]

Uniprot Accession IDs

Gene Name

MYF6

Ensembl ID

ENST00000228641
ENSP00000228641
ENSG00000111046

Symbol

BHLHC4
MRF4
CNM3
MRF4
myf-6
bHLHc4

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9

molecular function	0.84

gene perturbation	0.82

cellular component	0.53

cell line	0.52

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.11 (req: < 5)

View Publications

Gene RIFs: 3 (req: <= 3)

View Gene RIFs

Antibodies: 230 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.11 (req: >= 5)

Gene RIFs: 3 (req: > 3)

Antibodies: 230 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (82)

Explore Interacting Targets

1 – 10 of 82

See Interactions on String-DB

TCF4

Tbio

Family: TF

Novelty: 0.0019718

p_int: 0.999999942

p_ni: 5.8e-8

Score: 0.981

Data Source: BioPlex,STRINGDB

TCF12

Tbio

Family: TF

Novelty: 0.00381424

p_int: 0.999999926

p_ni: 7.4e-8

Score: 0.979

Data Source: BioPlex,STRINGDB

TCF3

Tbio

Family: TF

Novelty: 0.00112675

p_int: 0.99999991

p_ni: 9e-8

Score: 0.979

Data Source: BioPlex,Reactome,STRINGDB

NES

Tbio

Novelty: 0.00035379

p_int: 0.999989783

p_ni: 0.000010217

Score: 0.706

Data Source: BioPlex,STRINGDB

ID4

Tbio

Family: TF

Novelty: 0.00399089

p_int: 0.999896469

p_ni: 0.000100174

p_wrong: 0.000003357

Score: 0.729

Data Source: BioPlex,STRINGDB

MAPK14

Tchem

Family: Kinase

Novelty: 0.00045138

p_int: 0.999390132

p_ni: 0.000609868

Score: 0.923

Data Source: BioPlex,STRINGDB

IRGC

Tbio

Family: Enzyme

Novelty: 0.10743948

p_int: 0.996994194

p_ni: 0.003005801

p_wrong: 5e-9

Score: 0.177

Data Source: BioPlex,STRINGDB

TBC1D4

Tbio

Novelty: 0.00549202

p_int: 0.956321185

p_ni: 0.043678815

Score: 0.186

Data Source: BioPlex,STRINGDB

DISC1

Tbio

Novelty: 0.00183442

p_int: 0.941832052

p_ni: 0.058165018

p_wrong: 0.00000293

Score: 0.177

Data Source: BioPlex,STRINGDB

KAT14

Tbio

Novelty: 0.17168043

p_int: 0.925933178

p_ni: 0.074066815

p_wrong: 6e-9

Score: 0.305

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (2)

PathwayCommons (2)

WikiPathways (1)

Developmental Biology (R-HSA-1266738)

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Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Reactome	Myogenesis	29 targets	R-HSA-525793

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738

Myogenesis	29 targets	R-HSA-525793

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (6)

Components (3)

Processes (13)

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Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

protein heterodimerization activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Complete proteome

Developmental protein

Differentiation

Disease mutation

DNA-binding

Myogenesis

Nucleus

Reference proteome

MGI Phenotype

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IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID
Chimp	myogenic factor 6	VGNC:5494	745321

Macaque	myogenic factor 6		697306

Mouse	myogenic factor 6	MGI:97253	17878

Rat	myogenic factor 6	RGD:3134	25714

Dog	myogenic factor 6	VGNC:43534	611531

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myogenic factor 6

Macaque	myogenic factor 6

Mouse	myogenic factor 6

Rat	myogenic factor 6

Dog	myogenic factor 6

Publication Statistics

PubMed Score 167.11

PubMed score by year

PubTator Score 60.19

PubTator score by year

Related Publications

Text Mined References (19)

GeneRif Annotations (3)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
embryo phenotype

mortality/aging

muscle phenotype

respiratory system phenotype

skeleton phenotype

vision/eye phenotype