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Tbio
MYF5
Myogenic factor 5

Protein Summary
Description
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228644
  • ENSP00000228644
  • ENSG00000111049

Symbol
  • BHLHC2
  • EORVA
  • bHLHc2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
molecular function
0.84
tissue
0.69
virus perturbation
0.68
phenotype
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.975
Data Source:  Reactome,STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.969
Data Source:  Reactome,STRINGDB
MEF2A
Tbio
Family:  TF
Novelty:  0.00439393
Score:  0.961
Data Source:  Reactome,STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.957
Data Source:  STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
Score:  0.952
Data Source:  STRINGDB
PAX7
Tbio
Family:  TF
Novelty:  0.00142843
Score:  0.952
Data Source:  STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.941
Data Source:  STRINGDB
MYF6
Tbio
Family:  TF
Novelty:  0.00509046
Score:  0.937
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.925
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (59)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myogenic factor 5
VGNC:5493
467081
Macaque
myogenic factor 5
697426
Mouse
MGI:97252
17877
Rat
RGD:1308322
299766
Dog
myogenic factor 5
VGNC:43533
482582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myogenic factor 5
Macaque
myogenic factor 5
Mouse
Rat
Dog
myogenic factor 5
Publication Statistics
PubMed Score 406.65
PubMed score by year
PubTator Score 128.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title