Tbio MYD88 Myeloid differentiation primary response protein MyD88

Protein Summary

Description

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q99836
• B4DKH8
• B4DKU4
• B4DQ60
• B4DQ72
• J3KPU4
• J3KQ87
• J3KQJ6
• P78397
• Q53XS7

Gene Name

• MYD88

Ensembl ID

• ENST00000396334
• ENSP00000379625
• ENSG00000172936
• ENST00000424893
• ENSP00000389979
• ENST00000495303
• ENSP00000417848

Symbol

• MYD88D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.96
transcription factor binding site profile	0.84
transcription factor perturbation	0.8
disease	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Myeloid Differentiation Primary Response Protein Myd88

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Myeloid Differentiation Primary Response Protein Myd88

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3203.14   (req: < 5)

Gene RIFs: 454   (req: <= 3)

Antibodies: 882   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3203.14   (req: >= 5)

Gene RIFs: 454   (req: > 3)

Antibodies: 882   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0