Tbio MYCL Protein L-Myc

Protein Summary

Uniprot Accession IDs

• P12524
• A2A2C9
• B4DJH2
• Q14897
• Q5QPL0
• Q5QPL1
• Q9NUE9

Gene Name

• MYCL

Ensembl ID

• ENST00000372815
• ENSP00000361902
• ENSG00000116990
• ENST00000372816
• ENSP00000361903
• ENST00000397332
• ENSP00000380494

Symbol

• BHLHE38
• LMYC
• MYCL1
• LMYC
• L-Myc
• MYCL1
• bHLHe38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.89
transcription factor binding site profile	0.78
microRNA	0.69
histone modification site profile	0.65
cell type or tissue	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Protein L-myc

Protein / Nucleic Acid Binding / Protein L-myc

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Protein L-myc

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.23   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.23   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

KLC3

Tbio

Novelty:  0.0528937

p_int:  0.99999996

p_ni:  1.1e-8

p_wrong:  2.9e-8

Score:  0.625

Data Source:  BioPlex,STRINGDB

KLC4

Tdark

Novelty:  0.32552746

p_int:  0.999999937

p_ni:  6.3e-8

Data Source:  BioPlex

KAT5

Tchem

Family:  Epigenetic

Novelty:  0.00368348

p_int:  0.999999658

p_ni:  3.41e-7

p_wrong:  1e-9

Score:  0.727

Data Source:  BioPlex,STRINGDB

EPC1

Tbio

Novelty:  0.03216371

p_int:  0.999999269

p_ni:  7.31e-7

Score:  0.72

Data Source:  BioPlex,STRINGDB

ING3

Tbio

Family:  Epigenetic

Novelty:  0.01696145

p_int:  0.999999259

p_ni:  7.41e-7

Score:  0.749

Data Source:  BioPlex,STRINGDB

EPC2

Tbio

Novelty:  0.02760809

p_int:  0.99999829

p_ni:  0.00000171

Score:  0.724

Data Source:  BioPlex,STRINGDB

EP400

Tbio

Novelty:  0.02013098

p_int:  0.999997088

p_ni:  0.000002912

Score:  0.785

Data Source:  BioPlex,STRINGDB

KIF5A

Tbio

Novelty:  0.01277095

p_int:  0.999996918

p_ni:  0.000003082

Data Source:  BioPlex

TRRAP

Tbio

Novelty:  0.01517245

p_int:  0.999996668

p_ni:  0.000003332

Score:  0.752

Data Source:  BioPlex,STRINGDB

KLC2

Tbio

Novelty:  0.06284367

p_int:  0.99999333

p_ni:  0.00000667

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (3)

Components (1)

Processes (1)

Find Similar Targets

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1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Traceable Author Statement (TAS)	UniProtKB
protein dimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	2	2		76.6
mean platelet volume	EFO_0004584	2	2	2		76.4
hemoglobin measurement	EFO_0004509	2	2	2		75.6
hematocrit	EFO_0004348	2	2	2		70.2
red blood cell distribution width	EFO_0005192	2	2	2		64.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2		76.6
mean platelet volume	EFO_0004584	2		76.4
hemoglobin measurement	EFO_0004509	2		75.6
hematocrit	EFO_0004348	2		70.2
red blood cell distribution width	EFO_0005192	2		64.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
DNA-binding
Nucleus
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
hematocrit
hemoglobin measurement
lymphocyte count
mean corpuscular volume
mean platelet volume
myeloid white cell count
platelet count
platelet crit
red blood cell density measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MYCL proto-oncogene, bHLH transcription factor	VGNC:14803	469291
Macaque	MYCL proto-oncogene, bHLH transcription factor		716497
Mouse	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived	MGI:96799	16918
Rat	MYCL proto-oncogene, bHLH transcription factor	RGD:1588591	298506
Dog	MYCL proto-oncogene, bHLH transcription factor	VGNC:43529	482461

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MYCL proto-oncogene, bHLH transcription factor
Macaque	MYCL proto-oncogene, bHLH transcription factor
Mouse	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived
Rat	MYCL proto-oncogene, bHLH transcription factor
Dog	MYCL proto-oncogene, bHLH transcription factor

Publication Statistics

PubMed Score 250.23

PubMed score by year

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PubTator Score 187.07

PubTator score by year

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Related Publications

Text Mined References (38)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title