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Tbio
MYCBP2
E3 ubiquitin-protein ligase MYCBP2

Protein Summary
Description
Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357337
  • ENSP00000349892
  • ENSG00000005810
  • ENST00000544440
  • ENSP00000444596

Symbol
  • KIAA0916
  • PAM
  • PAM
  • Phr
  • PHR1
  • Myc-bp2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.99
transcription factor perturbation
0.91
virus perturbation
0.88
interacting protein
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.26   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.26   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999991508
p_ni:  0.000008492
Score:  0.585
Data Source:  BioPlex,STRINGDB
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
p_int:  0.999985544
p_ni:  0.000014456
Data Source:  BioPlex
FBXW7
Tbio
Novelty:  0.00180856
p_int:  0.999979573
p_ni:  0.000020427
Score:  0.275
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.999952839
p_ni:  0.000047158
p_wrong:  3e-9
Data Source:  BioPlex
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.999840277
p_ni:  0.000159723
Score:  0.164
Data Source:  BioPlex,STRINGDB
EPHB2
Tchem
Family:  Kinase
Novelty:  0.00211785
p_int:  0.999796533
p_ni:  0.000203468
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.998477909
p_ni:  0.001522091
Score:  0.179
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.998466033
p_ni:  0.001533967
p_wrong:  1e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
TXNIP
Tbio
Novelty:  0.00216952
p_int:  0.99721176
p_ni:  0.00278824
Data Source:  BioPlex
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.994995649
p_ni:  0.005004351
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
6
4
1.1
96.1
circadian rhythm
1
1
0
1.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
1.1
96.1
circadian rhythm
0
1.2
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MYC binding protein 2, E3 ubiquitin protein ligase
696734
Mouse
MGI:2179432
105689
Rat
RGD:1312048
290447
Dog
MYC binding protein 2, E3 ubiquitin protein ligase
VGNC:43528
476952
Horse
MYC binding protein 2, E3 ubiquitin protein ligase
VGNC:20468
100053014
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MYC binding protein 2, E3 ubiquitin protein ligase
Mouse
Rat
Dog
MYC binding protein 2, E3 ubiquitin protein ligase
Horse
MYC binding protein 2, E3 ubiquitin protein ligase
Publication Statistics
PubMed Score 160.26
PubMed score by year
PubTator Score 262.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title