MYCBP
c-Myc-binding protein
Protein Summary
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC. The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000397572
- ENSP00000380702
- ENSG00000214114
- AMY1
- AMY-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
transcription factor perturbation | 0.8 | ||
microRNA | 0.79 | ||
virus perturbation | 0.76 | ||
small molecule perturbation | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.58 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 196 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.58 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 196 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0