Tchem MYC Myc proto-oncogene protein

Protein Summary

Description

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P01106
• A8WFE7
• P01107
• Q14026

Gene Name

• MYC

Ensembl ID

• ENST00000377970
• ENSP00000367207
• ENSG00000136997
• ENST00000613283
• ENSP00000479618

Symbol

• BHLHE39
• MRTL
• MYCC
• c-Myc
• bHLHe39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
gene perturbation	1
hub protein	1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myc Proto-oncogene Protein

Protein / Nucleic Acid Binding / Myc Proto-oncogene Protein

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myc Proto-oncogene Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18689.88   (req: < 5)

Gene RIFs: 2234   (req: <= 3)

Antibodies: 3768   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18689.88   (req: >= 5)

Gene RIFs: 2234   (req: > 3)

Antibodies: 3768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0