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Tchem
MYC
Myc proto-oncogene protein

Protein Summary
Description
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377970
  • ENSP00000367207
  • ENSG00000136997
  • ENST00000613283
  • ENSP00000479618

Symbol
  • BHLHE39
  • MRTL
  • MYCC
  • c-Myc
  • bHLHe39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
gene perturbation
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18689.88   (req: < 5)
Gene RIFs: 1612   (req: <= 3)
Antibodies: 3768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18689.88   (req: >= 5)
Gene RIFs: 1612   (req: > 3)
Antibodies: 3768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0