MYBPC3
Myosin-binding protein C, cardiac-type
Protein Summary
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
- ENST00000545968
- ENSP00000442795
- ENSG00000134571
- FHC
- CMH4
- CMD1MM
- LVNC10
- MYBP-C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase | 0.85 | ||
protein domain | 0.85 | ||
cell type or tissue | 0.76 | ||
biological term | 0.74 | ||
gene perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 386.47 (req: < 5)
Gene RIFs: 140 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 386.47 (req: >= 5)
Gene RIFs: 140 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (126)
Nearest Tclin Targets
Pathways (10)
Reactome (2)
KEGG (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Muscle contraction | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (9)
Components (9)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (74)
Items per page:
1 – 5 of 74
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 11 | 21 | 31 | 99.6 | |||||
apolipoprotein A 1 measurement | 2 | 11 | 12 | 98.8 | |||||
IGF-1 measurement | 1 | 8 | 8 | 96.1 | |||||
triglyceride measurement | 4 | 8 | 8 | 96 | |||||
C-reactive protein measurement | 4 | 7 | 8 | 95.3 | |||||
Items per page:
1 – 5 of 74
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 31 | 99.6 | |||||
apolipoprotein A 1 measurement | 12 | 98.8 | |||||
IGF-1 measurement | 8 | 96.1 | |||||
triglyceride measurement | 8 | 96 | |||||
C-reactive protein measurement | 8 | 95.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myosin binding protein C, cardiac | 451168 | ||||||
Macaque | myosin binding protein C, cardiac | 712093 | ||||||
Mouse | MGI:102844 | 17868 | ||||||
Rat | RGD:1305950 | 295929 | ||||||
Dog | myosin binding protein C, cardiac | VGNC:43524 | 483624 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myosin binding protein C, cardiac | |||||
Macaque | myosin binding protein C, cardiac | |||||
Mouse | ||||||
Rat | ||||||
Dog | myosin binding protein C, cardiac | |||||
Publication Statistics
PubMed Score 386.47
PubMed score by year
PubTator Score 302.22
PubTator score by year
Related Publications
Text Mined References (205)
GeneRif Annotations (140)
Items per page:
0 of 0
PMID | Year | Title |
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