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Tbio
MYB
Transcriptional activator Myb

Protein Summary
Description
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341911
  • ENSP00000339992
  • ENSG00000118513
  • ENST00000367812
  • ENSP00000356786
  • ENST00000367814
  • ENSP00000356788
  • ENST00000442647
  • ENSP00000410825
  • ENST00000525369
  • ENSP00000435938
  • ENST00000525477
  • ENSP00000437081
  • ENST00000525514
  • ENSP00000435578
  • ENST00000528774
  • ENSP00000434723
  • ENST00000529586
  • ENSP00000437264
  • ENST00000533384
  • ENSP00000432811
  • ENST00000533624
  • ENSP00000436605
  • ENST00000533808
  • ENSP00000435293
  • ENST00000533837
  • ENSP00000434639
  • ENST00000534044
  • ENSP00000435055
  • ENST00000534121
  • ENSP00000432851

Symbol
  • efg
  • Cmyb
  • c-myb
  • c-myb_CDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
gene perturbation
0.98
hub protein
0.97
transcription factor
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.3   (req: < 5)
Gene RIFs: 192   (req: <= 3)
Antibodies: 856   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.3   (req: >= 5)
Gene RIFs: 192   (req: > 3)
Antibodies: 856   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (249)
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.994
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.991
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.985
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.981
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.979
Data Source:  STRINGDB
NLK
Tchem
Family:  Kinase
Novelty:  0.01512201
Score:  0.979
Data Source:  STRINGDB
PAX5
Tbio
Family:  TF
Novelty:  0.0012666
Score:  0.97
Data Source:  STRINGDB
MAF
Tbio
Family:  TF
Novelty:  0.00040887
Score:  0.969
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.967
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Developmental Biology
ESR-mediated signaling
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
13
10
7
6
99.8
mean corpuscular volume
10
10
12
99.8
erythrocyte count
9
9
11
99.8
mean corpuscular hemoglobin concentration
11
8
12
99.7
hematocrit
9
7
10
99.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
6
99.8
mean corpuscular volume
12
99.8
erythrocyte count
11
99.8
mean corpuscular hemoglobin concentration
12
99.7
hematocrit
10
99.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene, transcription factor
VGNC:11127
463016
Macaque
MYB proto-oncogene, transcription factor
712321
Mouse
MGI:97249
17863
Rat
RGD:1560020
498982
Dog
MYB proto-oncogene, transcription factor
VGNC:43518
483995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYB proto-oncogene, transcription factor
Macaque
MYB proto-oncogene, transcription factor
Mouse
Rat
Dog
MYB proto-oncogene, transcription factor
Publication Statistics
PubMed Score 1106.30
PubMed score by year
PubTator Score 1080.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title