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Tdark
MXRA8
Matrix remodeling-associated protein 8

Protein Summary
Description
May play a role in the maturation and maintenance of blood-brain barrier. (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309212
  • ENSP00000307887
  • ENSG00000162576
  • ENST00000342753
  • ENSP00000344998
  • ENST00000445648
  • ENSP00000399229
  • ENST00000477278
  • ENSP00000436135

Symbol
  • ASP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.84
gene perturbation
0.68
cell type or tissue
0.62
small molecule perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
APP
Tclin
Novelty:  0.00008964
Score:  0.938
Data Source:  STRINGDB
APLP2
Tbio
Novelty:  0.0082936
Score:  0.93
Data Source:  STRINGDB
TNC
Tbio
Novelty:  0.0052441
Score:  0.919
Data Source:  STRINGDB
GAS6
Tbio
Novelty:  0.00297606
Score:  0.918
Data Source:  STRINGDB
FBN1
Tbio
Novelty:  0.00074957
Score:  0.916
Data Source:  STRINGDB
LAMB2
Tbio
Novelty:  0.07966931
Score:  0.915
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.914
Data Source:  STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.914
Data Source:  STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
Score:  0.914
Data Source:  STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
67.9
intraocular pressure measurement
1
2
2
60.2
1
1
0
1.1
44.6
Drugs affecting bone structure and mineralization use measurement
1
1
1
11.4
corneal resistance factor
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.9
intraocular pressure measurement
2
60.2
0
1.1
44.6
Drugs affecting bone structure and mineralization use measurement
1
11.4
corneal resistance factor
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
matrix remodeling associated 8
705989
Mouse
MGI:1922011
74761
Rat
RGD:1359356
313770
Dog
matrix remodeling associated 8
VGNC:53426
489592
Cow
matrix remodeling associated 8
VGNC:50222
522392
Species
Name
OMA
EggNOG
Inparanoid
Macaque
matrix remodeling associated 8
Mouse
Rat
Dog
matrix remodeling associated 8
Cow
matrix remodeling associated 8
Publication Statistics
PubMed Score 259.59
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title