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Tbio
MXD3
Max dimerization protein 3

Protein Summary
Description
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423571
  • ENSP00000389716
  • ENSG00000213347
  • ENST00000427908
  • ENSP00000416921
  • ENST00000439742
  • ENSP00000401867
  • ENST00000513063
  • ENSP00000421463

Symbol
  • BHLHC13
  • MAD3
  • MYX
  • MAD3
  • BHLHC13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
small molecule perturbation
0.77
transcription factor binding site profile
0.76
virus perturbation
0.76
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MNT
Tbio
Family:  TF
Novelty:  0.0088423
p_int:  0.999987197
p_ni:  1.17e-7
p_wrong:  0.000012685
Score:  0.422
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
p_int:  0.99969809
p_ni:  0.00030191
Score:  0.742
Data Source:  BioPlex,STRINGDB
SAP30L
Tbio
Family:  Enzyme
Novelty:  0.20174722
p_int:  0.99967001
p_ni:  0.000328884
p_wrong:  0.000001106
Score:  0.535
Data Source:  BioPlex,STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
p_int:  0.999534269
p_ni:  0.000465731
Score:  0.641
Data Source:  BioPlex,STRINGDB
ARID4B
Tbio
Family:  TF; Epigenetic
Novelty:  0.04182223
p_int:  0.99949017
p_ni:  0.00050983
Score:  0.219
Data Source:  BioPlex,STRINGDB
SAP130
Tdark
Family:  Enzyme
Novelty:  1.85084032
p_int:  0.999292828
p_ni:  0.000707157
p_wrong:  1.4e-8
Score:  0.655
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.998942215
p_ni:  0.001057784
p_wrong:  1e-9
Score:  0.682
Data Source:  BioPlex,STRINGDB
BRMS1L
Tbio
Novelty:  0.01578276
p_int:  0.99848845
p_ni:  0.001511549
p_wrong:  1e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
TSPYL2
Tbio
Novelty:  0.03720016
p_int:  0.997450698
p_ni:  0.002549302
Data Source:  BioPlex
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.994621729
p_ni:  0.000010788
p_wrong:  0.005367483
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
body weights and measures
1
2
2
94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
hematocrit
5
96.1
hemoglobin measurement
4
94.3
body weights and measures
2
94
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
MAX dimerization protein 3
VGNC:51904
489093
Horse
MAX dimerization protein 3
100058486
Cow
MAX dimerization protein 3
533359
Pig
MAX dimerization protein 3
100512157
Opossum
MAX dimerization protein 3
100031892
Species
Name
OMA
EggNOG
Inparanoid
Dog
MAX dimerization protein 3
Horse
MAX dimerization protein 3
Cow
MAX dimerization protein 3
Pig
MAX dimerization protein 3
Opossum
MAX dimerization protein 3
Publication Statistics
PubMed Score 21.52
PubMed score by year
PubTator Score 37.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title