Tbio MVP Major vault protein

Protein Summary

Description

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q14764
• Q96BG4
• Q9BPW6
• Q9BQT1
• Q9UBD1
• MVP

Gene Name

• MVP

Ensembl ID

• ENST00000357402
• ENSP00000349977
• ENSG00000013364
• ENST00000395353
• ENSP00000378760

Symbol

• LRP
• LRP
• VAULT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
interacting protein	0.92
disease perturbation	0.9
gene perturbation	0.88
small molecule perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Major Vault Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Major Vault Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.67   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 668   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.67   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0