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Tbio
MUM1
PWWP domain-containing protein MUM1

Protein Summary
Description
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311401
  • ENSP00000309135
  • ENSG00000160953
  • ENST00000415183
  • ENSP00000394925

Symbol
  • EXPAND1
  • MUM1
  • MUM-1
  • EXPAND1
  • HSPC211
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cell type or tissue
0.74
histone modification site profile
0.72
tissue sample
0.65
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
EVPL
Tbio
Novelty:  0.00274279
p_int:  0.9990895
p_ni:  0.0009105
Data Source:  BioPlex
BAIAP2L1
Tbio
Novelty:  0.06381886
p_int:  0.998496153
p_ni:  0.001503752
p_wrong:  9.5e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.997502592
p_ni:  0.002493743
p_wrong:  0.000003665
Data Source:  BioPlex
EPPK1
Tdark
Novelty:  0.03621061
p_int:  0.99658998
p_ni:  0.00341002
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.993449031
p_ni:  0.006550969
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.988523784
p_ni:  0.011475925
p_wrong:  2.91e-7
Data Source:  BioPlex
PPL
Tbio
Novelty:  0.00684645
p_int:  0.987793399
p_ni:  0.012206582
p_wrong:  1.9e-8
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.98049267
p_ni:  0.019507317
p_wrong:  1.3e-8
Data Source:  BioPlex
IGHG2
Tclin
p_int:  0.97686818
p_ni:  0.022005198
p_wrong:  0.001126622
Data Source:  BioPlex
SERPINB1
Tbio
Family:  Enzyme
Novelty:  0.00267786
p_int:  0.970554548
p_ni:  0.02910408
p_wrong:  0.000341372
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
13.5
hematocrit
1
1
1
13.5
pulse pressure measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
13.5
hematocrit
1
13.5
pulse pressure measurement
1
12.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915364
68114
Rat
RGD:1308340
362838
Cow
melanoma associated antigen (mutated) 1
513471
Pig
PWWP domain-containing protein MUM1
100511862
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
melanoma associated antigen (mutated) 1
Pig
PWWP domain-containing protein MUM1
Publication Statistics
PubMed Score 6.29
PubMed score by year
PubTator Score 113.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title