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Tbio
MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

Protein Summary
Description
Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is par ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264198
  • ENSP00000264198
  • ENSG00000090432

Symbol
  • C1orf166
  • GIDE
  • MAPL
  • MULAN
  • RNF218
  • GIDE
  • MAPL
  • MULAN
  • RNF218
  • C1orf166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
histone modification site profile
0.81
cell type or tissue
0.79
molecular function
0.7
small molecule perturbation
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.85   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.85   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
BZW2
Tbio
Novelty:  0.17006204
p_int:  0.999982863
p_ni:  0.000017137
Data Source:  BioPlex
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.999918989
p_ni:  0.000081011
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999888172
p_ni:  0.000111828
Score:  0.29
Data Source:  BioPlex,STRINGDB
TRHDE
Tbio
Family:  Enzyme
Novelty:  0.02084006
p_int:  0.99917077
p_ni:  0.00082923
Score:  0.185
Data Source:  BioPlex,STRINGDB
ARMC6
Tdark
Novelty:  0.58706267
p_int:  0.99896257
p_ni:  0.00103743
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.992675188
p_ni:  0.007324812
Data Source:  BioPlex
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.991029756
p_ni:  0.008970244
Score:  0.173
Data Source:  BioPlex,STRINGDB
GSDME
Tbio
Novelty:  0.01231123
p_int:  0.990596442
p_ni:  0.009403556
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
STK36
Tbio
Family:  Kinase
Novelty:  0.0963277
p_int:  0.98931773
p_ni:  0.009820483
p_wrong:  0.000861787
Data Source:  BioPlex
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.984802863
p_ni:  0.015197133
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
84.6
mean corpuscular volume
1
1
1
83.5
alkaline phosphatase measurement
2
2
1
8.4
76.1
apolipoprotein A 1 measurement
1
1
1
71.5
lymphocyte count
2
2
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
84.6
mean corpuscular volume
1
83.5
alkaline phosphatase measurement
1
8.4
76.1
apolipoprotein A 1 measurement
1
71.5
lymphocyte count
2
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial E3 ubiquitin protein ligase 1
VGNC:1340
456590
Mouse
MGI:1915600
68350
Rat
RGD:1309944
298576
Dog
mitochondrial E3 ubiquitin protein ligase 1
VGNC:43501
487394
Horse
mitochondrial E3 ubiquitin protein ligase 1
VGNC:20443
100058446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
mitochondrial E3 ubiquitin protein ligase 1
Horse
mitochondrial E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 125.85
PubMed score by year
PubTator Score 47.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title