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Tbio
MUC20
Mucin-20

Protein Summary
Description
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000445522
  • ENSP00000405629
  • ENSG00000176945
  • ENST00000447234
  • ENSP00000414350
  • ENST00000610415
  • ENSP00000479947
  • ENSG00000278114
  • ENST00000615394
  • ENSP00000483878
  • ENSG00000276583
  • ENST00000620530
  • ENSP00000479182
  • ENSG00000275501
  • ENST00000625274
  • ENSP00000485837
  • ENST00000627739
  • ENSP00000485855
  • ENST00000630334
  • ENSP00000485921

Symbol
  • KIAA1359
  • MUC-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
biological process
0.68
cellular component
0.61
tissue sample
0.61
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.48   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.48   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999994307
p_ni:  0.000005693
Data Source:  BioPlex
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
p_int:  0.995902525
p_ni:  0.004097454
p_wrong:  2.2e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
TRMT44
Tdark
Family:  Enzyme
Novelty:  0.27902923
p_int:  0.993901145
p_ni:  0.006098855
Score:  0.179
Data Source:  BioPlex,STRINGDB
RBM15
Tbio
Novelty:  0.00948292
p_int:  0.990541224
p_ni:  0.009458776
Score:  0.165
Data Source:  BioPlex,STRINGDB
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.980927315
p_ni:  0.018928246
p_wrong:  0.000144439
Data Source:  BioPlex
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.975643717
p_ni:  0.024356283
Data Source:  BioPlex
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.974724289
p_ni:  0.023849509
p_wrong:  0.001426202
Data Source:  BioPlex
RAD51B
Tbio
Novelty:  0.00302521
p_int:  0.95164372
p_ni:  0.048332776
p_wrong:  0.000023504
Data Source:  BioPlex
RANGRF
Tbio
Family:  Enzyme
Novelty:  0.02750539
p_int:  0.934918113
p_ni:  0.010953157
p_wrong:  0.054128731
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.917671084
p_ni:  0.082328916
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
1
1
70.8
lung disease associated with cystic fibrosis
1
1
1
70.8
lung disease associated with cystic fibrosis
1
1
1
70.8
lung disease associated with cystic fibrosis
1
1
1
70.8
glomerular filtration rate
1
1
0
5.6
15.1
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
70.8
lung disease associated with cystic fibrosis
1
70.8
lung disease associated with cystic fibrosis
1
70.8
lung disease associated with cystic fibrosis
1
70.8
glomerular filtration rate
0
5.6
15.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mucin 20, cell surface associated
713400
Mouse
MGI:2385039
224116
Rat
RGD:1304865
303886
Dog
mucin 20, cell surface associated
VGNC:43500
488023
Horse
mucin 20, cell surface associated
VGNC:20441
100070072
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mucin 20, cell surface associated
Mouse
Rat
Dog
mucin 20, cell surface associated
Horse
mucin 20, cell surface associated
Publication Statistics
PubMed Score 29.48
PubMed score by year
PubTator Score 14.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title