Tdark MUC19 Mucin-19

Protein Summary

Description

May function in ocular mucus homeostasis. This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are responsible for the gel-like properties of mucus. The encoded protein may be involved in disruption of the ocular surface in Sjogren syndrome. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q7Z5P9
• G3CIG0
• Q8NA85
• MUC-19

Gene Name

• MUC19

Symbol

• MUC-19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.83
virus perturbation	0.64
cell type or tissue	0.57
phenotype	0.39
biological term	0.35

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (0)

No protein-protein interactions found

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (3)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
Golgi lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
Polymorphism
Reference proteome
Repeat
Secreted
Signal

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubTator Score 16.41

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (12)

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PMID	Year	Title