Tbio MUC15 Mucin-15

Protein Summary

Description

May play a role in the cell adhesion to the extracellular matrix.

Uniprot Accession IDs

• Q8N387
• B3KY00
• E9PII6
• F8W945
• Q6UWS3
• Q8IXI8
• Q8WW41
• MUC-15

Gene Name

• MUC15

Ensembl ID

• ENST00000455601
• ENSP00000397339
• ENSG00000169550

Symbol

• PAS3
• MUC-15
• PASIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
virus perturbation	0.85
microRNA	0.47
cellular component	0.46
cell type or tissue	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.27   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.27   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

FCRL4

Tbio

Novelty:  0.03750876

p_int:  0.997232447

p_ni:  0.002765484

p_wrong:  0.000002069

Score:  0.556

Data Source:  BioPlex,STRINGDB

CDS1

Tbio

Family:  Enzyme

Novelty:  0.08094799

p_int:  0.80204044

p_ni:  0.006048315

p_wrong:  0.191911244

Score:  0.455

Data Source:  BioPlex,STRINGDB

MUC20

Tbio

Novelty:  0.04645313

Score:  0.981

Data Source:  STRINGDB

MUC13

Tbio

Novelty:  0.01282861

Score:  0.979

Data Source:  STRINGDB

MUC17

Tbio

Novelty:  0.03624836

Score:  0.978

Data Source:  STRINGDB

MUC12

Tbio

Novelty:  0.04323645

Score:  0.978

Data Source:  STRINGDB

MUC21

Tbio

Novelty:  0.02583488

Score:  0.975

Data Source:  STRINGDB

MUC16

Tbio

Novelty:  0.00444587

Score:  0.972

Data Source:  STRINGDB

MUC4

Tbio

Novelty:  0.00193208

Score:  0.971

Data Source:  STRINGDB

MUC3A

Tbio

Novelty:  0.0576775

Score:  0.971

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
Golgi lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Secreted
Signal
Transmembrane

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mucin 15, cell surface associated		451084
Macaque	mucin 15, cell surface associated		700194
Mouse	mucin 15	MGI:2442110	269328
Rat	mucin 15, cell surface associated	RGD:1589864	690914
Dog	mucin 15, cell surface associated	VGNC:43499	102154062

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mucin 15, cell surface associated
Macaque	mucin 15, cell surface associated
Mouse	mucin 15
Rat	mucin 15, cell surface associated
Dog	mucin 15, cell surface associated

Publication Statistics

PubMed Score 48.27

PubMed score by year

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PubTator Score 29.22

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title