Tchem MUC1 Mucin-1

Protein Summary

Description

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P15941
• A5YRV1
• A6ZID9
• A6ZIE0
• B1AVQ8
• B1AVR0
• B6ECA1
• E7ESE5
• E7EUG9
• P13931
• P15942
• P17626
• Q0VAP5
• Q0VAP6
• Q14128
• Q14876
• Q16437
• Q16442
• Q16615
• Q6S4Y3
• Q7Z547
• Q7Z548
• Q7Z550
• Q7Z552
• Q9BXA4
• Q9UE75
• Q9UE76
• Q9UQL1
• Q9Y4J2
• MUC-1

Gene Name

• MUC1

Ensembl ID

• ENST00000337604
• ENSP00000338983
• ENSG00000185499
• ENST00000342482
• ENSP00000342814
• ENST00000343256
• ENSP00000339690
• ENST00000368389
• ENSP00000357374
• ENST00000368390
• ENSP00000357375
• ENST00000368392
• ENSP00000357377
• ENST00000368393
• ENSP00000357378
• ENST00000368396
• ENSP00000357381
• ENST00000368398
• ENSP00000357383

Symbol

• PUM
• EMA
• MCD
• PEM
• PUM
• KL-6
• MAM6
• MCKD
• PEMT
• CD227
• H23AG
• MCKD1
• MUC-1
• ADMCKD
• ADMCKD1
• CA 15-3
• MUC-1/X
• MUC1/ZD
• MUC-1/SEC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
hub protein	0.94
transcription factor binding site profile	0.89
biological term	0.86
PubMedID	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4594.21   (req: < 5)

Gene RIFs: 687   (req: <= 3)

Antibodies: 4111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4594.21   (req: >= 5)

Gene RIFs: 687   (req: > 3)

Antibodies: 4111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL4443554

MUC1Tchem

pKd : 7.52

Protein-Protein Interactions (267)

Explore Interacting Targets

1 – 10 of 267

• See Interactions on String-DB

ATP6V0A2

Tbio

Family:  Enzyme

Novelty:  0.00504614

p_int:  0.998303237

p_ni:  0.001696763

Score:  0.581

Data Source:  BioPlex,STRINGDB

TMEM199

Tbio

Novelty:  0.05799147

p_int:  0.997257064

p_ni:  0.002742936

p_wrong:  1e-9

Score:  0.725

Data Source:  BioPlex,STRINGDB

ATP6V0A1

Tbio

Family:  Enzyme

Novelty:  0.02009317

p_int:  0.99486767

p_ni:  0.00513233

Score:  0.512

Data Source:  BioPlex,STRINGDB

ATP11C

Tbio

Family:  Transporter

Novelty:  0.05441047

p_int:  0.986544526

p_ni:  0.013455474

Score:  0.18

Data Source:  BioPlex,STRINGDB

TMEM59L

Tbio

Novelty:  0.22745646

p_int:  0.980141019

p_ni:  0.017778292

p_wrong:  0.002080688

Score:  0.167

Data Source:  BioPlex,STRINGDB

TMEM63B

Tdark

Family:  IC

Novelty:  0.25017412

p_int:  0.969438936

p_ni:  0.030507086

p_wrong:  0.000053978

Score:  0.363

Data Source:  BioPlex,STRINGDB

MYADM

Tbio

Novelty:  0.11475375

p_int:  0.956313447

p_ni:  0.035221676

p_wrong:  0.008464878

Data Source:  BioPlex

TMEM67

Tbio

Novelty:  0.02573267

p_int:  0.945454153

p_ni:  0.054545778

p_wrong:  6.9e-8

Data Source:  BioPlex

CCDC115

Tbio

Novelty:  0.23966137

p_int:  0.906874013

p_ni:  0.015442421

p_wrong:  0.077683566

Score:  0.716

Data Source:  BioPlex,STRINGDB

TNFSF9

Tbio

Novelty:  0.00532152

p_int:  0.902260737

p_ni:  0.097739263

Score:  0.232

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (18)

PathwayCommons (1)

WikiPathways (2)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (3)

Components (8)

Processes (11)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription coregulator activity	Inferred from Direct Assay (IDA)	BHF-UCL
p53 binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (50)

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1 – 5 of 50

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	3	6	5	3.7	99.1
urate measurement	EFO_0004531	6	6	10		98.6
serum urea measurement	EFO_0009795	2	4	4		97.3
reticulocyte measurement	EFO_0010700	3	2	4		93.8
cancer antigen 15.3 measurement	EFO_0010585	1	2	2		93.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 50

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	5	3.7	99.1
urate measurement	EFO_0004531	10		98.6
serum urea measurement	EFO_0009795	4		97.3
reticulocyte measurement	EFO_0010700	4		93.8
cancer antigen 15.3 measurement	EFO_0010585	2		93.8

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Autocatalytic cleavage
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Lipoprotein

GWAS Trait Find Similar Targets

No Header	No Header
1,5 anhydroglucitol measurement
age at onset
albuminuria
allergy
appendicular lean mass
aspartate aminotransferase measurement
biological sex
blood urea nitrogen measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
neoplasm

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 4594.21

PubMed score by year

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PubTator Score 3133.15

PubTator score by year

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Related Publications

Text Mined References (756)

GeneRif Annotations (687)

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PMID	Year	Title