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Tchem
MUC1
Mucin-1

Protein Summary
Description
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337604
  • ENSP00000338983
  • ENSG00000185499
  • ENST00000342482
  • ENSP00000342814
  • ENST00000343256
  • ENSP00000339690
  • ENST00000368389
  • ENSP00000357374
  • ENST00000368390
  • ENSP00000357375
  • ENST00000368392
  • ENSP00000357377
  • ENST00000368393
  • ENSP00000357378
  • ENST00000368396
  • ENSP00000357381
  • ENST00000368398
  • ENSP00000357383

Symbol
  • PUM
  • EMA
  • MCD
  • PEM
  • PUM
  • KL-6
  • MAM6
  • MCKD
  • PEMT
  • CD227
  • H23AG
  • MCKD1
  • MUC-1
  • ADMCKD
  • ADMCKD1
  • CA 15-3
  • MUC-1/X
  • MUC1/ZD
  • MUC-1/SEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
hub protein
0.94
transcription factor binding site profile
0.89
biological term
0.86
PubMedID
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: < 5)
Gene RIFs: 687   (req: <= 3)
Antibodies: 4111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: >= 5)
Gene RIFs: 687   (req: > 3)
Antibodies: 4111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (267)
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.998303237
p_ni:  0.001696763
Score:  0.581
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.997257064
p_ni:  0.002742936
p_wrong:  1e-9
Score:  0.725
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.99486767
p_ni:  0.00513233
Score:  0.512
Data Source:  BioPlex,STRINGDB
ATP11C
Tbio
Family:  Transporter
Novelty:  0.05441047
p_int:  0.986544526
p_ni:  0.013455474
Score:  0.18
Data Source:  BioPlex,STRINGDB
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.980141019
p_ni:  0.017778292
p_wrong:  0.002080688
Score:  0.167
Data Source:  BioPlex,STRINGDB
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.969438936
p_ni:  0.030507086
p_wrong:  0.000053978
Score:  0.363
Data Source:  BioPlex,STRINGDB
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.956313447
p_ni:  0.035221676
p_wrong:  0.008464878
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.945454153
p_ni:  0.054545778
p_wrong:  6.9e-8
Data Source:  BioPlex
CCDC115
Tbio
Novelty:  0.23966137
p_int:  0.906874013
p_ni:  0.015442421
p_wrong:  0.077683566
Score:  0.716
Data Source:  BioPlex,STRINGDB
TNFSF9
Tbio
Novelty:  0.00532152
p_int:  0.902260737
p_ni:  0.097739263
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Cytokine Signaling in Immune system
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Cytokine Signaling in Immune system
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (67)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
6
10
99.2
blood urea nitrogen measurement
7
4
7
98.9
serum gamma-glutamyl transferase measurement
4
7
6
3.7
98.7
4
4
0
1.3
98.7
serum urea measurement
2
4
4
97.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
10
99.2
blood urea nitrogen measurement
7
98.9
serum gamma-glutamyl transferase measurement
6
3.7
98.7
0
1.3
98.7
serum urea measurement
4
97.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 5211.25
PubMed score by year
PubTator Score 3133.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title