Protein Summary
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface ...more
- ENST00000337604
- ENSP00000338983
- ENSG00000185499
- ENST00000342482
- ENSP00000342814
- ENST00000343256
- ENSP00000339690
- ENST00000368389
- ENSP00000357374
- ENST00000368390
- ENSP00000357375
- ENST00000368392
- ENSP00000357377
- ENST00000368393
- ENSP00000357378
- ENST00000368396
- ENSP00000357381
- ENST00000368398
- ENSP00000357383
- PUM
- EMA
- MCD
- PEM
- PUM
- KL-6
- MAM6
- MCKD
- PEMT
- CD227
- H23AG
- MCKD1
- MUC-1
- ADMCKD
- ADMCKD1
- CA 15-3
- MUC-1/X
- MUC1/ZD
- MUC-1/SEC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.97 | ||
hub protein | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
biological term | 0.86 | ||
PubMedID | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4594.21 (req: < 5)
Gene RIFs: 687 (req: <= 3)
Antibodies: 4111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4594.21 (req: >= 5)
Gene RIFs: 687 (req: > 3)
Antibodies: 4111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (267)
ATP6V0A2
Family: Enzyme
Novelty: 0.00504614
p_int: 0.998303237
p_ni: 0.001696763
Score: 0.581
Data Source: BioPlex,STRINGDB
TMEM199
Novelty: 0.05799147
p_int: 0.997257064
p_ni: 0.002742936
p_wrong: 1e-9
Score: 0.725
Data Source: BioPlex,STRINGDB
ATP6V0A1
Family: Enzyme
Novelty: 0.02009317
p_int: 0.99486767
p_ni: 0.00513233
Score: 0.512
Data Source: BioPlex,STRINGDB
ATP11C
Family: Transporter
Novelty: 0.05441047
p_int: 0.986544526
p_ni: 0.013455474
Score: 0.18
Data Source: BioPlex,STRINGDB
TMEM59L
Novelty: 0.22745646
p_int: 0.980141019
p_ni: 0.017778292
p_wrong: 0.002080688
Score: 0.167
Data Source: BioPlex,STRINGDB
TMEM63B
Family: IC
Novelty: 0.25017412
p_int: 0.969438936
p_ni: 0.030507086
p_wrong: 0.000053978
Score: 0.363
Data Source: BioPlex,STRINGDB
MYADM
Novelty: 0.11475375
p_int: 0.956313447
p_ni: 0.035221676
p_wrong: 0.008464878
Data Source: BioPlex
TMEM67
Novelty: 0.02573267
p_int: 0.945454153
p_ni: 0.054545778
p_wrong: 6.9e-8
Data Source: BioPlex
CCDC115
Novelty: 0.23966137
p_int: 0.906874013
p_ni: 0.015442421
p_wrong: 0.077683566
Score: 0.716
Data Source: BioPlex,STRINGDB
TNFSF9
Novelty: 0.00532152
p_int: 0.902260737
p_ni: 0.097739263
Score: 0.232
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (18)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Cytokine Signaling in Immune system | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (8)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 6 | 5 | 3.7 | 99.1 | ||||
urate measurement | 6 | 6 | 10 | 98.6 | |||||
serum urea measurement | 2 | 4 | 4 | 97.3 | |||||
reticulocyte measurement | 3 | 2 | 4 | 93.8 | |||||
cancer antigen 15.3 measurement | 1 | 2 | 2 | 93.8 | |||||
Items per page:
1 – 5 of 50
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 5 | 3.7 | 99.1 | ||||
urate measurement | 10 | 98.6 | |||||
serum urea measurement | 4 | 97.3 | |||||
reticulocyte measurement | 4 | 93.8 | |||||
cancer antigen 15.3 measurement | 2 | 93.8 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 4594.21
PubMed score by year
PubTator Score 3133.15
PubTator score by year
Related Publications
Text Mined References (756)
GeneRif Annotations (687)
Items per page:
0 of 0
PMID | Year | Title |
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