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Tbio
MTX1
Metaxin-1

Protein Summary
Description
Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316721
  • ENSP00000317106
  • ENSG00000173171
  • ENST00000368376
  • ENSP00000357360
  • ENST00000609421
  • ENSP00000476632

Symbol
  • MTX
  • MTXN
  • MTX
  • MTXN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
disease perturbation
0.93
histone modification site profile
0.91
transcription factor perturbation
0.68
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.16   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.16   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.999872581
p_ni:  0.000127419
Score:  0.185
Data Source:  BioPlex,STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.983709971
p_ni:  0.016290029
Data Source:  BioPlex
GNRH1
Tbio
Novelty:  0.00020807
p_int:  0.982340572
p_ni:  0.01765534
p_wrong:  0.000004088
Score:  0.227
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.976931849
p_ni:  0.023068151
Data Source:  BioPlex
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
p_int:  0.97084787
p_ni:  0.02915213
Score:  0.181
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.960972366
p_ni:  0.039027634
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.953397081
p_ni:  0.046602919
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.94247054
p_ni:  0.05752946
Score:  0.232
Data Source:  BioPlex,STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.887845888
p_ni:  0.112153831
p_wrong:  2.81e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.880609781
p_ni:  0.11939021
p_wrong:  1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Reactome
Organelle biogenesis and maintenance
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Mitochondrial protein import
Organelle biogenesis and maintenance
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (65)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
5
9
99
blood urea nitrogen measurement
7
4
7
98.9
4
4
0
1.3
98.7
serum gamma-glutamyl transferase measurement
4
5
4
3.7
98.3
serum urea measurement
2
3
3
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
99
blood urea nitrogen measurement
7
98.9
0
1.3
98.7
serum gamma-glutamyl transferase measurement
4
3.7
98.3
serum urea measurement
3
97
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metaxin 1
VGNC:1339
100610982
Macaque
metaxin 1
717595
Mouse
MGI:103025
17827
Rat
RGD:1559791
295241
Dog
metaxin 1
VGNC:53621
480130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metaxin 1
Macaque
metaxin 1
Mouse
Rat
Dog
metaxin 1
Publication Statistics
PubMed Score 80.16
PubMed score by year
PubTator Score 314.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title