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Tbio
MTUS2
Microtubule-associated tumor suppressor candidate 2

Protein Summary
Description
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380808
  • ENSP00000370186
  • ENSG00000132938
  • ENST00000542829
  • ENSP00000445403

Symbol
  • CAZIP
  • KIAA0774
  • TIP150
  • ICIS
  • CAZIP
  • TIP150
  • KIAA0774
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
cell type or tissue
0.74
phenotype
0.68
tissue sample
0.68
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MTUS1
Tbio
Novelty:  0.01066081
p_int:  0.999992111
p_ni:  0.000007887
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.999786157
p_ni:  0.000213843
Data Source:  BioPlex
ATP11C
Tbio
Family:  Transporter
Novelty:  0.05441047
p_int:  0.998488127
p_ni:  0.001511873
Data Source:  BioPlex
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.996094178
p_ni:  0.00390581
p_wrong:  1.2e-8
Data Source:  BioPlex
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.994571762
p_ni:  0.005428234
p_wrong:  4e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.99245456
p_ni:  0.007545358
p_wrong:  8.1e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.99216118
p_ni:  0.007838817
p_wrong:  4e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.984352257
p_ni:  0.015647743
Data Source:  BioPlex
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.983553626
p_ni:  0.016446366
p_wrong:  8e-9
Data Source:  BioPlex
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.981551557
p_ni:  0.018440206
p_wrong:  0.000008237
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diuretic use measurement
1
1
1
42.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diuretic use measurement
1
42.3
Agents acting on the renin-angiotensin system use measurement
1
37.6
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915388
77521
Dog
microtubule associated scaffold protein 2
VGNC:43497
486023
Cow
microtubule associated scaffold protein 2
VGNC:31757
616677
Pig
microtubule associated scaffold protein 2
100157816
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
microtubule associated scaffold protein 2
Cow
microtubule associated scaffold protein 2
Pig
microtubule associated scaffold protein 2
Publication Statistics
PubMed Score 7.77
PubMed score by year
PubTator Score 3.38
PubTator score by year
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Related Publications
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PMID
Year
Title