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Tbio
MTUS1
Microtubule-associated tumor suppressor 1

Protein Summary
Description
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262102
  • ENSP00000262102
  • ENSG00000129422
  • ENST00000297488
  • ENSP00000297488
  • ENST00000381861
  • ENSP00000371285
  • ENST00000381869
  • ENSP00000371293
  • ENST00000519263
  • ENSP00000430167
  • ENST00000544260
  • ENSP00000445738
  • ENST00000634613
  • ENSP00000489288

Symbol
  • ATBP
  • ATIP
  • GK1
  • KIAA1288
  • MTSG1
  • ATBP
  • ATIP
  • ICIS
  • MP44
  • ATIP3
  • MTSG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
kinase perturbation
0.84
transcription factor perturbation
0.84
microRNA
0.82
transcription factor
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.71   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2079.71   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0