Tbio MTSS1 Metastasis suppressor protein 1

Protein Summary

Description

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Uniprot Accession IDs

• O43312
• J3KNK6
• Q8TCA2
• Q96RX2

Gene Name

• MTSS1

Ensembl ID

• ENST00000325064
• ENSP00000322804
• ENSG00000170873
• ENST00000378017
• ENSP00000367256
• ENST00000431961
• ENSP00000393606
• ENST00000518547
• ENSP00000429064

Symbol

• KIAA0429
• MIM
• MIM
• MIMA
• MIMB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.99
virus perturbation	0.85
small molecule perturbation	0.8
biological process	0.75

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Metastasis Suppressor Protein 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Metastasis Suppressor Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.65   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.65   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0